Multiple Sclerosis
Conditions
Brief summary
The aim of this study is to investigate the relationship between cognitive impairment and retinal nerve fiber layer & ganglion cell inner plexiform layer in MS.
Detailed description
Cross-sectional study design, including 60 patients and 30 healthy controls. Subjects were investigated clinically, underwent retinal optical coherence tomography (OCT) and comprehensive cognitive assessments. The correlation between these modalities was evaluated by Spearman correlation.
Interventions
DIAGNOSTIC_TESTOCT
The degree of physical disability was assessed by using the Expanded Disability Status Scale (EDSS). The EDSS score ranges from 0 to 10 in 0.5 unit increments that represent higher levels of disability. Neurocognitive functions were evaluated using the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) that includes the following tests: 1. Symbol Digit Modalities Test (SDMT) that is used for assessment of information processing speed. 2. California Verbal Learning Test - 2nd edition (CVLT-II) . 3. Brief Visuospatial Memory Test-Revised (BVMT-R) OCT assessment was performed by spectral domain-optical coherence tomography to assess the retinal nerve fiber layer thickness and macular volume in humans . Each eye for every patient was assessed by measuring the thickness of RNFL and GCC, respecting presence or absence of the previous history of optic neuritis (ON).
Sponsors
Mansoura University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 45 Years
Inclusion criteria
* 60 MS patients diagnosed according to the revised McDonald criteria 2010 were included * 30 healthy subjects with age and sex match control group.
Exclusion criteria
* Medical disorder other than MS that may grossly affect cognitive functions * Pregnancy, * Previous neurological or neuropsychiatric disorders, * Alcohol or drug abuse, * MRI findings which could not be attributed to MS. * Severe visual disorders (\> ± 6.0 dpt.) * History of ocular surgery, glaucoma or diabetes.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Optical coherence tomography | 24-48 hours | OCT imaging was performed by spectral domain-optical coherence tomography to assess the retinal thickness. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive assessment | 24-48 hours | Neurocognitive functions were evaluated using the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) |
| Expanded Disability Status Scale (EDSS) | 24 hours | The EDSS score ranges from 0 to 10 in 0.5 unit increments that represent higher levels of disability. |
Countries
Egypt
Outcome results
None listed