Milrinone on Cardiac Performance During Off-pump Coronary Artery Bypass Surgery

Milrinone on Cardiac Performance in Patients Undergoing Off-pump Coronary Artery Bypass Surgery

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04153383

Enrollment

Registered

2019-11-06

Start date

2024-09-30

Completion date

2024-12-31

Last updated

2023-09-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic Heart Disease

Keywords

Milrinone, diastolic function

Brief summary

The purpose of this study is to analyze the changes in cardiac performance before and after milrinone administration in order to find out whether milrinone improves LV performance in patients undergoing coronary artery bypass surgery.

Interventions

DRUGMilrinone Injection

giving IV milrinone: 50 mcg/kg loading dose by IV push over 10 minutes, then 0.375-0.75 mcg/kg/min IV

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

* patient agree and provide written informed consent. * patient undergoing elective coronary artery bypass graft surgery * preoperative LV EF\>50% (TTE)

Exclusion criteria

* preoperative cardiac dysrhythmia * preoperative IABP * use of other inotropic agents

Design outcomes

Primary

Measure	Time frame
TMAD of ticuspid annulus during early relaxation	15 mini after milrinone administration

Secondary

Measure	Time frame
global longitudinal strain of the right ventricle	15 mini after milrinone administration
left ventricular ejection fraction	15 min after milline administration
global longitudinal strain of the left ventricle	15 min after milline administration

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026