Pancreatic Diseases
Conditions
Brief summary
In most Asian medical centers, rapid on-site cytology evaluation is not available, the number of needle passes of EUS-FNA is decided by endoscopists. Full-field optical coherence tomography (FF-OCT) is a new optical imaging technique that could generate sectioning tomogram from fresh tissue and provide close-to-pathology depiction of the morphological structure and pathological changes in minutes without conventional tissue preparation, slicing, and staining, and dynamic cell imaging (DCI) added the viability information of cells/tissue, which could be more important in sample rapid evaluation.
Detailed description
Light-CT, a special-designed pathology-approximation system which is based on the lighting feature or dynamic feature of tissue and cells, is used to detect malignant cells or tissue in fresh specimens. Morphological structure and pathological changes could be captured in minutes, which implies a possible application in intraoperative diagnosis. The investigators aimed to evaluate the diagnostic efficacy of FFOCT for the tissue samples obtained from EUS-FNB of pancreas.
Interventions
Pancreatic tissue sample obtained by EUS-FNB will be used for FFOCT imaging. The Images will be sent to trained pathologists for diagnosis. The same tissue sample will be sent to the pathology department for routine histological examination. Compare the diagnoses made by the 2 different methods.
Sponsors
Changhai Hospital
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Tissue samples can be obtained via EUS-FNB * Signed informed consent letter
Exclusion criteria
* Unable or refuse to provide informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sensitivity of Light-CT | 1week after procedure | The true positive rate measures the proportion of positives that are correctly identified by Light-CT |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Sensitivity of Light-CT | 1week after procedure | The true negative rate measures the proportion of positives that are correctly identified by Light-CT |
| The diagnostic efficacy of Light-CT for different pancreatic diseases | 1week after procedure | Comparing the sensitivity and specificity of FFOCT in the diagnosis of different pancreatic diseases |
| coherence of FFOCT diagnoses by assistant and pathologist | 1week after procedure | comparing the diagnostic coherence of FFOCT by trained assistant( endoscopist) and trained pathologist |
Contacts
Primary ContactWei Zhou, M.D.
Outcome results
None listed