Recovery From Anesthesia
Conditions
Brief summary
Several clinical studies and case reports suggested that aminophylline antagonizes the effects of diazepam , barbiturates , sevoflurane ,morphineand propofol.However, the available results from uncontrolled clinical settings make it difficult to quantify the specific effects of aminophylline on hypnotics and anesthetics
Detailed description
Aminophylline, a theophylline derivative, exerts multiple pharmacological effects, either through phosphodiesterase inhibition (i.e., a potent bronchodilating action, which is often used for the treatment of bronchial asthma) or via adenosine receptor blockade .It is generally considered that the majority of actions ascribed to therapeutic doses of xanthines (caffeine and theophylline) are due to their action as adenosine receptor antagonists. To the best of the investigator's knowledge this hypothesis was not reported in patients scheduled for major pelvi-abdominal surgeries under general anesthesia , and aminophylline was not given as premedication to test this hypothesis as it was previously administrated after the end of surgery ,also it was recommended by previous clinical studies to evaluate the effective dose of aminophylline that affect the extubation and recovery time.
Interventions
DRUGAminophylline
the control group (n =15 ) the patients will receive 20 ml of normal saline IV ,20 minutes before induction of general anesthesia . Amiopphylline 2mg:(n = 15) the patients will receive 2 mg/kg intravenous (IV) aminophylline diluted in 20 ml normal saline 20 minutes before induction of general anesthesia . Aminophylline 4mg: (n = 15) the patients will receive 4 mg/kg intravenous (IV) aminophylline diluted in 20 ml normal saline 20 minutes before induction of general anesthesia .The study drugs will be given by an anesthetist unaware of the study protocol.
Sponsors
Beni-Suef University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients age: 20-60 years * Males and females patients * American Society Of Anesthesiology (ASA) physical status I- II .
Exclusion criteria
* Patient refusal to participate in this study * Patient with known sensitivity to aminophylline * Patients with history of cardiac failure * Patients with renal or hepatic dysfunction and in chronic alcoholism since clearance of aminophylline is decreased. * Patients with peptic ulcer, hyperthyroidism, glaucoma,as these conditions may be exacerbated. * Patients with opioid addiction * Current treatment with B agonists, anticholinergic agents, tranquilizers, anticonvulsants ,or antidepressants. * Pregnancy. * Habitual coffee consumption exceeding 2 cups per day.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| times to lose consciousness( LOC) | from the first second after administration of the anesthetic drugs and for 1-5 minutes | Times to lose of consciousness( LOC) which is defined as an OAA/S score 2 (loss of responsiveness to light tapping on shoulderor mild shaking with voice command to open eyes) |
Countries
Egypt
Contacts
Primary ContactSamaa ak Rashwan, MD
Outcome results
None listed