Respiratory Disease of A Newborn
Conditions
Keywords
RDS, CERCLAGE, CERVIX INSUFFICIENCY
Brief summary
Women with a history of cervical insufficiency can be managed with elective cervical cerclage placed at the beginning of the second trimester. The McDonald technique is the most commonly used. Though lack a robust scientific evidence, the cerclage is removed electively at 36-37 weeks of gestation in order to avoid maternal cervical laceration. In addition, the incidence of spontaneous delivery is nearly 20% within 72 hours after ceclage removal, thus elective cerclage removal at 36-37 weeks may also put the newborns at complications associated with iatrogenic late preterm/early term delivery
Detailed description
The optimal timing of cervical cerclage removal is yet unclear. In the present study we will evaluate maternal and neonatal outcome variables after elective removal of the cerclage, and may suggest a gestational week cut-off for optimal cerclage removal/ Primary outcome: Neonatal respiratory morbidity after cerclage removal. The respiratory outcome will be compared across each gestational week of delivery after cerclage removal, that is; group 1 (36-36.6 weeks), group 2 (37-37.6 weeks), group 3 (38-38.6 weeks), group 4 (beyond 39 weeks). Secondary outcomes: Time interval between cerclage removal and gestational age of delivery.
Interventions
Cervical cerclage and cervical cerclage removal
Sponsors
Study design
Eligibility
Inclusion criteria
* Singleton pregnancies * Elective or emergent cerclage in the current pregnancy * Cerclage that was removed after 36 weeks of pregnancy
Exclusion criteria
* Multiple pregnancies * Major congenital anomalies * Cerclage removal before 36weeks of pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cercalge removal and neonatal morbidity | 1 year | Neonatal respiratory morbidity after cerclage removal |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The optimal timing for cerclage removal | 1 year | Time interval between cerclage removal and gestational age of delivery. |
Countries
Israel