Adrenaline During Resuscitation From Pulseless Electrical Activity

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04149730

Enrollment

280

Registered

2019-11-04

Start date

2019-03-20

Completion date

2023-05-15

Last updated

2023-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Arrest

Keywords

Epinephrine, Pulseless electrical activity

Brief summary

This is a prospective observational study at St. Olavs hospital in Norway. Data are gathered from defibrillators that have been in use during resuscitation from cardiac arrest. Aim is to investigate the changes in electrocardiograms (ECG) during resuscitation from pulseless electrical activity (PEA), which is a type of cardiac arrest. ECG changes may be useful as a prognostic marker during resuscitation from PEA. In addition the researchers will describe the effect of adrenaline and chest compressions on clinical state transitions during resuscitation from pulseless electrical activity. Clinical state transitions are changes between different types of cardiac arrest. This study is expected to increase our understanding of the dynamics during treatment of cardiac arrest.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Cardiac arrest among hospitalized patients presenting with PEA as the primary rhythm.

Design outcomes

Primary

Measure	Time frame	Description
QRS frequency	Every 3 minutes from start till end of cardiopulmonary resuscitation	Measurement of RR intervals in milliseconds.
QRS width	Every 3 minutes from start till end of cardiopulmonary resuscitation	Measurement of the width of QRS complexes in milliseconds
Changes of clinical states	Every 3 minutes from start till end of cardiopulmonary resuscitation	changes of clinical states (for example from Pulseless electrical activity to Ventricular fibrillation) during treatment of cardiac arrest.

Countries

Norway, United States

Outcome results