Premature Ovarian Failure
Conditions
Keywords
Premature ovarian insuffiency, Infertility, PRP
Brief summary
All encountered cases with POI will be assessed and examined then investigated. Eligible cases will be included in the study
Detailed description
Patients will be subjected to injection of autologous PRP inside the ovary about 0.5-1 mml by laparoscopy
Interventions
PROCEDUREPRP injection inside the ovary by laparoscoy. The injection volume is 2 ml
intraovarian injection of 2 mml of PRP by laparoscopic guide
Sponsors
Tanta University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
All eligible patient will recieve the treatment with PRP
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Premature ovarian insufficiency diagnosed by: * FSH\> 40 Amenorrhea Menopuasal symptoms Infertility
Exclusion criteria
* Refusal to participate Secondary POI due chemotherapy, surgery, or radiotherapy Previous treatment with PRP
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Resumption of ovarian hormonal function | 3-6 months | Measurement of Estradiol level on Day 3 of cycle |
| Resumption of ovarian folliclugenesis | 3-6 months | Assessment of the presence of oocytes by trans vaginal ultrasound on day 3 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Resumption of menstruation | 3-6 months | Occurrence of Menstruation after secondary amenrorrhea by questionnaire |
| Fertility potential | 3-6 months | Potential to get pregnant after ICSI procedure |
Countries
Egypt
Outcome results
None listed