Tuberculosis Infection
Conditions
Brief summary
Diagnosis of active and latent pulmonary tuberculosis, as well as extrapulmonary tuberculosis, is still a major challenge of TB control in China. This observational study aims to evaluate TB-antigen responsive T cell markers in the diagnosis of tuberculosis and extrapulmonary tuberculosis and try to find new prompt and cost-effective laboratory tests for active TB screening.
Detailed description
The enrolled patients will be grouped into active or latent tuberculosis according to the bacteriological evidence of TB. The TB-antigen responsive T cell markers will be examined. The performance of each T cell marker for the diagnosis of active TB will be systematically evaluated.
Interventions
DIAGNOSTIC_TESTTB-antigen responsive T cell markers
A blood test including a series of T cell markers which are responsive to TB antigens
Sponsors
Tongji University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
7 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* any patients suspicious of TB infection * TB culture and Xpert test required * Chest X-ray required
Exclusion criteria
* anti-TB therapy before the sample collection.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Positive rate and negative rate | 2-3 month after sampling | Evaluation of the positive rate and negative rate for each T cell marker |
| Receiver operating characteristic curve | 2-3 month after sampling | The AUC of each T cell marker will be analyzed and compared |
Countries
China
Contacts
Primary ContactBO SU, Dr
Outcome results
None listed