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Erector Spinae Block, Epidural Analgesia and Intrathecal Analgesia in Thoracic Surgery

Efficacités comparées du Bloc Des Muscles érecteurs du Rachis, du Bloc péridural et de la rachianalgésie en Chirurgie Thoracique Majeure.

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04147754
Acronym
SPIRIT
Enrollment
200
Registered
2019-11-01
Start date
2019-11-04
Completion date
2021-02-28
Last updated
2019-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary Surgery

Brief summary

Pulmonary thoracic surgery is often responsible for severe postoperative pain, which is associated with an increase in postoperative morbidity and mortality. Moreover, postoperative thoracic pain has a strong impact on patient rehabilitation and is associated with an increase in hospital stay. Various analgesic techniques allow effective management of pain in the context of thoracic surgery. Regional anesthesia, particularly, allows a powerful analgesia, and limits the use of opioids and their side effects. Among regional anesthesia techniques, thoracic epidural analgesia has become the gold standard for post-thoracotomy analgesia. However, it induces a sympathetic block that promotes in particular per and postoperative hypotension and acute urinary retentions. Thus, new regional anesthesia techniques have been developed and assessed in thoracic surgery in order to avoid side effects related to epidural analgesia, particularly paravertebral block and erector spinae block, but also intrathecal analgesia. Paravertebral block has shown analgesic efficacy after thoracic surgery, and its interest in reducing the risk of hypotension, acute urinary retention, pruritus and postoperative nausea and vomiting compared with the epidural analgesia. Erector spinae block, recently described and evaluated in this context of thoracic surgery, seems to have the same interests and to be easier to achieve than the paravertebral block, but has been little studied. Finally, intrathecal morphine is frequently used because of an easy and rapid realization, and because it allows an adequate analgesia and the reduction of the duration of stay in intensive care compared to the epidural one. However, despite its frequent use, very few studies have compared intrathecal anesthesia with the epidural and other peri-spinal blocks. These three types of analgesia, epidural analgesia, intrathecal morphine, and erector spinae block are regional anesthesia methods regularly used for pulmonary surgery in the department of the investigators. All of these techniques have shown their analgesic efficacy, but each seems to have particular respective interests, in terms of achievement, management, or perioperative rehabilitation. The objective of the investigators study is to evaluate the effectiveness of each of its techniques to treat postoperative pain and improve the rehabilitation of these patients.

Interventions

PROCEDUREEpidural anesthesia

Preoperative epidural anesthesia at physician discretion

PROCEDUREIntrathecal morphine

Preoperative intrathecal morphine at physician discretion

PROCEDUREErector spinae block

Preoperative erector spinae block at physician discretion

Sponsors

University Hospital, Angers
Lead SponsorOTHER_GOV

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum

Inclusion criteria

* Thoracic surgery for pulmonary resection * Scheduled regional anesthesia: epidural anesthesia, intrathecal morphine or erector spinae block

Exclusion criteria

* No epidural anesthesia or no intrathecal morphine or no erector spinae block performed

Design outcomes

Primary

MeasureTime frameDescription
Pain assessment at H+48Day 2 after surgeryNumerical pain rating scale: 0 (no pain at all) to 10 (worst imaginable pain)

Secondary

MeasureTime frameDescription
Length of stay in intensive care unitThrough study completion, an average of 1 year
Length of hospital stayThrough study completion, an average of 1 year
Total consumption of morphine (per and postoperative)Hour 2, Day 1, Day 2 and Day 3 after surgery.
Frequency of adverse effects related to morphine Frequency of morphine side effectsHour 2, Day 1, Day 2 and Day 3 after surgery.
Postoperative pain assessment at other timesHour 2, Day 1, and Day 3 after surgery.Numerical pain rating scale: 0 (no pain at all) to 10 (worst imaginable pain)
Impact on respiratory functionDay 1, Day 2 and Day 3 after surgery.Peak Flow in L/min

Countries

France

Contacts

Primary ContactEmmanuel Rineau, MD
erineau@live.fr+33241353951
Backup ContactLaurent Beydon, MD PHD
+33241353951

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026