Continous Glucose Measurement, Glycaemic Index, Postprandial Glucose Response
Conditions
Brief summary
Self-monitoring of blood glucose using capillary glucose testing has a number of shortcomings compared to continuous glucose monitoring (CGM). We aimed to compare these two methods and used blood glucose measurements in venous blood as a reference. Despite considerable inter-individual variability of postprandial glycemic responses, CGM evaluated postprandial glycemic excursions which had comparable results compared to standard blood glucose measurements under real-life conditions.
Detailed description
Self-monitoring of blood glucose using capillary glucose testing (C) has a number of shortcomings compared to continuous glucose monitoring (CGM). We aimed to compare these two methods and used blood glucose measurements in venous blood (IV) as a reference. Postprandial blood glucose levels were measured after 50 g oral glucose load and after the consumption of a portion of different foods containing 50 g of carbohydrates. We also evaluated the associations between postprandial glucose responses and the clinical characteristics of the participants at the beginning of the study. Incremental area under the curve (AUCi) of postprandial blood glucose was calculated for 1 h (AUCi 0-60) and 2 h (AUCi 0-120). Despite considerable inter-individual variability of postprandial glycemic responses, CGM evaluated postprandial glycemic excursions which had comparable results compared to standard blood glucose measurements under real-life conditions.
Interventions
DEVICEDetermination of postprandial glucose response by continuous glucose measurement after consuming different carbohydrate containing foods
One day prior to the study beginning, participants were equipped with a CGM system (FreeStyle Libre®, Abbott Diabetes Care, Alameda, CA, USA). This CGM system provides glucose recordings every 15 min over a period of 14 days. The glucose data were downloaded manually by a scan with a handheld device. On the second day of the study, participants consumed portions of these three test products containing 50 g of available carbohydrate on 3 separate days without a washout period. The products were tested in random order at the same time of the morning after a 10 h overnight fast. Venous blood samples were collected at 0, 15, 30, 45, 60, 75, 90, 105 and 120 min postprandial by inserting an intravenous cannula into a forearm vein. Capillary blood samples were obtained through finger pricking. Blood glucose levels in these samples were measured with a high quality SMBG system (ContourXT/Contour next, Ascensia Diabetes Care, Leverkusen, Deutschland, Germany).
Sponsors
Bionorica SE
West German Center of Diabetes and Health
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-80 years old
Exclusion criteria
* acute diseases, severe illness with in-patient treatment during the last 3 months, weight change \>2 kg/week during the last month, smoking secession during the last 3 months, drugs for active weight reduction, chronic medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postprandial glucose response | 1 and 2 hours after food consumption | postprandial glycemic changes after consuming different carbohydrate containing foods |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| incremental AUC (AUCi) of postprandial glucose excursions | 1 and 2 hours after food consumption | after consuming different carbohydrate containing foods |
Countries
Germany
Outcome results
None listed