Psoriasis
Conditions
Brief summary
Psoriasis is a chronic, immune-mediated inflammatory skin disease that is associated with substantial impairment of physical and psychological quality of life. The conventional treatment protocols manages the condition but with remissions and relapses which create anxiety in patients. Many of the patients withdraw from active social life as the disease attains chronicity. Several studies are pointing towards a conjoint management strategy incorporating the traditional and alternate medical systems. In this regard, Ayurveda is commonly used by psoriatic patients in India. Considering this fact it is high time to conduct a study to scientifically evaluate the efficacy of Ayurvedic treatment protocol in managing psoriasis as well as its potential to improve the quality of life.
Interventions
DRUGIndividualized internal ayurvedic treatment
All possible internal preparations will be administered for a period of 12 months. All administered preparations with its dosage and duration will be documented All preparations will be subjected to lab test for clearing heavy metal and pesticide content before the administration
OTHERExternal ayurvedic treatment
Application of warm external oil (Ayyapala kera tailam) on affected parts twice daily
Sponsors
Poomulli Neelakandan Namboodiripad Memorial Ayurveda Medical College
Universität Duisburg-Essen
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with psoriasis having age 18 years or more * Patients with moderate-to-severe plaque psoriasis with a PASI score of 12 or higher * Psoriasis diagnosed 6 months or more before study entry * Those who are poorly controlled based on physicians assessment with topical treatments, phototherapy, systemic therapy, or a combination of these therapies. * Participants who have given informed consent.
Exclusion criteria
* Participants with other systemic illnesses * Lactating and pregnant mothers. * Alcohol dependence/Narcotic dependence /Steroid dependence * In the judgment of the investigator, unable or unwilling to follow the protocol and instructions
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Psoriasis-specific quality of life | 6 months | Psoriasis specific DLQI scores |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Psoriasis Severity | 3 months | Psoriasis Area Severity Index (PASI) score |
| Psoriasis-specific quality of life | 3 months | Psoriasis specific DLQI scores |
| Adverse events | 3 months | — |
Countries
India
Outcome results
None listed