Cardiovascular Diseases, Thromboprophylaxis, Vascular Disease, Peripheral
Conditions
Keywords
Heparin-binding protein, Heparin, Biomarker
Brief summary
Heparin-Binding protein is a protein from primary and secretory granluae of white blood cells. It is released when white blood cells become activated and has been advocated as a biomarker for sepsis. The aim of this study is to find out if Heparins in clinical doses can change the level of Heparin-binding protein in plasma.
Detailed description
Blood samples are taken from patients before and after Heparins in clinical doses. The effects of heparins on Heparin-binding protein concentration in plasma is measured. This is a small observational study.
Interventions
DIAGNOSTIC_TESTBlood samples for Heparin-binding protein measurement
Blood samples before and after given heparin
Sponsors
Karolinska Institutet
Halla Halldorsdottir
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Planned endovascular treatment of aortic aneurysm or peripheral vascular surgery where unfractionated heparin in \>3000 units are given perioperatively * Planned subcutaneous low molecular weight heparin as a thromboprophylactic treatment after major surgery or on Intensive Care treated patients. * Planned open heart surgery with cardiopulmonary bypass.
Exclusion criteria
* Under 18 years * Unable to get informed consent from patient or relative
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in the level of Heparin-binding protein | Repeated blood sampling during minimum of 1 hour and maximum of 5 hours after given heparin | Blood samples are taken before and after given heparin |
Countries
Sweden
Outcome results
None listed