Hypoparathyroidism Postprocedural
Conditions
Keywords
Sclerostin, Hypoparathyroidism
Brief summary
To investigate changes in sclerostin levels following acute post-thyroidectomy hypoparathyroidism
Detailed description
Female patients with thyroid disorders, referred to the Department of Head and Neck Surgery, at Metaxa Anti-Cancer Hospital of Piraeus, for total thyroidectomy. Based on the development of biochemical hypocalcemia (cCa \< 8.4 mg/dl), subjects were divided into 2 groups: Group A: without postsurgical hypoparathyroidism that served as controls and group B: subjects, with acute postsurgical hypoparathyroidism. Blood collections were performed in the morning after an overnight fast, in at least 3 different time points; preoperatively, 1st postoperative day and 7th postoperative day for the detrmination of sclerostin levels
Interventions
DRUGcalcium carbonate and alphacalcidol
treatment for hypocalcemia
Sponsors
University of Athens
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Indication for total thyroidectomy
Exclusion criteria
* parathyroid disorders, chronic kidney disease (eGFR\< 60 ml/min), treatment with antiosteoporosis drugs, rheumatic disease and history of long term (\>1 month) or current corticosteroid use
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change in circulating serum sclerostin levels (pmol/L) during the observation period | 7 days | change in circulating serum sclerostin levels (pmol/L)during the observation period |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the between groups difference in % changes of circulating sclerostin | 7 days | the between groups difference in % changes of circulating sclerostin |
Countries
Greece
Outcome results
None listed