Gestational Diabetes
Conditions
Keywords
gestational diabetes, pregnancy, exercise
Brief summary
Gestational diabetes (GDM) impacts 1 in 10 pregnancies; hyperglycemia and hypertriglyceridemia are common features of the condition. Women are recommended to do at least 150 minutes of moderate-intensity aerobic activity a week during pregnancy and the postpartum period. Exercise both during and out of pregnancy has been shown to be an effective non-pharmacologic tool to reduce glucose and lipid profiles. The goals and purpose of this pilot study is to 1) determine the influence of exercise and the timing of exercise surrounding a meal on glucose and lipid metabolism in pregnant women with GDM and 2) determine the feasibility of low-resistance and aerobic activity and measuring exercise metrics during pregnancy. The overarching objective of this study is to determine the effects of low-resistance and aerobic exercise on glucose and lipids following a meal in pregnant women with GDM.
Detailed description
Gestational diabetes (GDM) impacts 1 in 10 pregnancies; hyperglycemia and hypertriglyceridemia are common features of the condition. Women are recommended to do at least 150 minutes of moderate-intensity aerobic activity a week during pregnancy and the postpartum period. Exercise both during and out of pregnancy has been shown to be an effective non-pharmacologic tool to reduce glucose and lipid profiles. The goals and purpose of this pilot study is to 1) determine the influence of exercise and the timing of exercise surrounding a meal on glucose and lipid metabolism in pregnant women with GDM and 2) determine the feasibility of low-resistance and aerobic activity and measuring exercise metrics during pregnancy. The overarching objective of this study is to determine the effects of low-resistance and aerobic exercise on glucose and lipids following a meal in pregnant women with GDM. Women will perform either low-resistance or aerobic exercise. Blood will be taken before and 2 hours after a fixed meal. For safety, women will have supervised exercise and oxygen consumption will be measured throughout the activity.
Interventions
BEHAVIORALphysical activity
exercise
Sponsors
Oregon Health and Science University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Intervention model description
all women with diet and lifestyle controlled gestational diabetes. each will serve as their own control
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* diet and lifestyle controlled gestational diabetes * Gestational age 28 weeks-32 weeks gestation * Age 18-50 years * Singleton pregnancy
Exclusion criteria
* Chronic hypertension * Pregestational diabetes * History of peripartum cardiomyopathy * Any condition contraindicating for exercise * Taking any cardiovascular modifying medications (beta-blockers, calcium channel blockers, corticosteroids) * Asthma or other underlying lung disease that is equivalent or worse than persistent mild classification (defined as at least \>2 day/week asthmatic symptoms, 1-2x/month nighttime awakenings, \>2days/week short-acting beta-agonist use for symptom control, and minor limitations with normal activity; ≥2 exacerbations in 6 months requiring oral systemic corticosteroids, ≥4 wheezing episodes/1 year lasting \>1 day) * Congenital anomalies * Multifetal gestation * Current alcohol use * Current tobacco use
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| postprandial glucose | 2 hours after meal | glucose measure after meal following exercise compared to no exercise |
| postprandial triglyceride | 2 hours after meal | triglyceride measure after meal following exercise compared to no exercise |
Countries
United States
Contacts
Primary ContactAmy M Valent, DO
Backup ContactMichaela Rickert, PA
Outcome results
None listed