Respiratory Syncytial Virus Infections, RSV Bronchiolitis, RSV Infection, Syncytial Virus Respiratory Infection
Conditions
Brief summary
The VRS (Respiratory Syncytial Virus) study group in Lyon is a working that aims to understand, predict and prevent the burden of disease caused by human respiratory syncytial virus (RSV) infection in infants. Incidence of RSV-associated hospitalization in the first year of life was estimated at 14.5 (95% CI 13.4-15.6) per 1000 births in a cohort study in Lyon, France. Related direct medical annual costs were estimated for this cohort at 364,269€, mostly attributed to children born during the RSV season (231,959€) and children born premature (108,673€). This study will combine existing hospital specimens and databases to determine the respective role of socio demographic factors, clinical risk factors, level of cord specific antibody at birth, and virus characteristic in the Respiratory Syncytial Virus (RSV) Hospitalization outcome in Infants. Regarding the introduction of a new RSV vaccine and RSV-specific neutralizing antibodies, these data are of prime importance to guide future vaccine policies.
Detailed description
Objective: To determine the main predictors of Respiratory Syncytial Virus (RSV) Hospitalizations in Infants Study design: Prospective epidemiological, observational, one-center cohort study with sample collection. Study population: Birth cohort of infants born in Lyon before and during the RSV circulation period (October to march) with a follow-up until one year old (from birth until the age of 1 year maximum): * Estimate Birth cohort (n=5,000). * Estimate number of RSVH case (n=110). * Estimate number of Blood cordon associated with a RSVH (Respiratory Syncytial Virus Human) case (n=60)
Interventions
OTHERNot applicable (no intervention)
Not applicable (no intervention)
Sponsors
Hospices Civils de Lyon
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Days to 4 Days
Healthy volunteers
Yes
Inclusion criteria
* Children born alive at participating centers. * Parents living in the Rhone Alpes Auvergne region
Exclusion criteria
* Parents non-willing to participate * Parents living outside the region
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of cases included in the cohort with RT-PCR (Retrotranscription) confirmed RSV hospitalization occurring from birth until the age of 1 year | 1 year after inclusion | Cases were defined as a new admission to one of the conventional pediatric hospital departments with a RSV positive sample during the hospital stay the first 3 years of life. |
| Number of cases included in the cohort with RT-PCR confirmed RSV hospitalization occurring from birth until the age of 3 years. | 3 years after inclusion | Cases were defined as a new admission to one of the conventional pediatric hospital departments with a RSV positive sample during the hospital stay the first 3 years of life. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Quantitative level of anti-RSV IgG measure | 3 years after inclusion | The quantitative level of anti-RSV IgG at birth in blood cord cordon will be compare between the cases group and the control group (No admission to one of the conventional pediatric hospital departments with a RSV positive sample during the hospital stay the first 3 years of life) |
| Quantitative level of anti-RSV IgG (Immunoglobulin G) measure | 3 years after inclusion | The quantitative level of anti-RSV IgG at birth in blood cord cordon will be compare between the cases group and the control group (No admission to one of the conventional pediatric hospital departments with a RSV positive sample during the hospital stay the first 3 years of life) |
Contacts
Primary ContactJean-Sebastien CASALEGNO, MD/PhD
Outcome results
None listed