Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
Conditions
Brief summary
ABG PARAMETERS ARE CHANGED DURING HIPEC, WE TRIED TO FIND COMPARISON BETWEEN NORADRENALINE AND PHENYLEPHRINE IN OPTIMIZING ABG PARAMETERS THAT REFLECTS ORGAN PERFUSIONS ESPECIALLY SERUM LACTATE
Detailed description
Arterial blood gas testing is considered one of the most important and widely used test in the detection of acidosis, alkalosis, electrolytes disturbance and tissue perfusion. in regard to tissue perfusion serum lactate above 4 mmol/L indicates poor tissue perfusion. serum lactate could be measured at ABG or separately. in this study we will test the effect of both noradrenaline and phenylephrine on lactate level at ABG during the stage of HIPAC in managing abdominal cancer patients.
Interventions
DRUGNORADRENALIN
DRUG THAT IS IMPROVING TISSUE AND ORGAN PERFUSION
DRUGPHENYLEPHRINE
DRUG THAT IS IMPROVING TISSUE AND ORGAN PERFUSION
Sponsors
Suez Canal University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
35 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* CANCER PATIENTS ENROLLED FOR HIPEC
Exclusion criteria
* DRUG SENSITIVITY
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| SERUM LACTATE IN ABG | IMMEDIATELY POSTOPERATIVELY | LANDMARK FOR TISSUE AND ORGAN PERFUSION |
Countries
Egypt
Outcome results
None listed