Endoscopic Submucosal Injection of Indocyanine Green
Conditions
Keywords
endoscopic submucosal injection, indocyanine green
Brief summary
Prospective registry study of endoscopic submucosal injection of indocyanine green before laparoscopic gastrectomy
Detailed description
To observe the imaging result of endoscopic submucosal injection of indocyanine green before laparoscopic gastrectomy, and analyze the relevant factors, so as to guide the operation of preoperative indocyanine green submucosal injection better. This study is prospective and observational. In order to analyze the related factors that affect the imaging effect, we enrolled patients who were to undergo indocyanine green fluorescence imaging for laparoscopic radical gastrectomy.
Interventions
PROCEDUREendoscopic submucosal injection of indocyanine green before laparoscopic gastrectomy
Indocyanine green was injected under endoscope within 24 hours before operation. Four points(0.5ml/point,1.25mg/ml) were evenly injected in four quadrants at the edge of the tumor. The injection method was direct submucosal injection and 0.5ml saline + 0.5ml indocyanine green solution + 0.5ml saline (sandwich method). The imaging effect was evaluated by indocyanine green fluorescence imaging system during the operation. The effect was divided into grade0 and Grade1. Grade1: The imaging of the tumor and the corresponding lymphatic drainage area in the injection area both were ideal. Grade 0: not up to grade 1, classified into tumor body and drainage area without imaging, only tumor body imaging, and even though tumor body and regional lymph drainage area imaging, the contrast agent in the gastric wall was too diffuse or even overflowing, which seriously interfered with the observation of lymph drainage area imaging.
Sponsors
Jilin University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* patients who were to undergo indocyanine green fluorescence imaging for laparoscopic radical gastrectomy.
Exclusion criteria
* have simultaneously other cancer * have severe systemic inflammatory disease ,serious illness such as diabetes, chronic lung diseases * have upper gastrointestinal surgery * Indocyanine green or iodine allergy * the period is too late or the tumor is too large to carry on a laparoscopy assisted radical distal gastrectomy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The imaging effect of indocyanine green | During the operation | The imaging effect was evaluated by indocyanine green fluorescence imaging system during the operation. The effect was divided into grade0 and Grade1. Grade1: The imaging of the tumor and the corresponding lymphatic drainage area in the injection area both were ideal. Grade 0: not up to grade 1, classified into tumor body and drainage area without imaging, only tumor body imaging, and even though tumor body and regional lymph drainage area imaging, the contrast agent in the gastric wall was too diffuse or even overflowing, which seriously interfered with the observation of lymph drainage area imaging. |
Countries
China
Contacts
Primary ContactHong Xu, Professor
Backup ContactDong Yang, Master
Outcome results
None listed