Growth, Premature
Conditions
Brief summary
This study aims to explore the relation of early nutritional intake, especially oral nutrition intake, with growth and body composition among very preterm or very low birth weight infants.
Detailed description
As the survival of very preterm infants increases, it is important to evaluate their long-term outcomes. Nutritional intake during early life was important to the growth and development in infants, especially in preterm infants. Studies found that early nutrition exposure in preterm infants can effect scored of Griffith Mental Development Scales and body fat percentage at later life. Insulin-like growth factor-1, leptin, Ghrelin, C-Peptide are associated with fat mass in children. And accumulation of fat and insulin resistance (IR) in the early postnatal period are related to metabolism diseases in adulthood. However, previous studies on nutrition and growth or the body composition of preterm infants were mostly completed in developed countries, and no relevant data were available in China. Therefore, this study aims to establish a prospective cohort of very preterm infants to observe the effects of nutritional exposure in early life on growth and body composition in later life.
Interventions
OTHEROral nutritional intake
The exposure are oral nutritional intake and all nutritional intake during early life (28 days), and insulin-like growth factor 1, leptin, Ghrelin, and C-peptide in serum at corrected age 40 gestational weeks.
Sponsors
Children's Hospital of Fudan University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Days to 18 Months
Healthy volunteers
No
Inclusion criteria
* infants born with a gestational age \>=28 weeks and \<32 weeks and/or a birth weight \>=1000g and \<1500g; * infants admitted to neonatal intensive care unit (NICU) of Children's hospital of Fudan University within 24h after birth.
Exclusion criteria
* major congenital anomalies or heredity metabolic diseases; * severe disease or abdominal surgery during hospitalization; * death during hospitalization or discharge without medical advice; * small for gestational age.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Z-scores of weight | at corrected age 40 gestational weeks | Computed according to the Fenton preterm growth standards (2013) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Z-scores of head circumference | at corrected age 40 gestational weeks | Computed according to the Fenton preterm growth standards (2013) |
| Z-scores of weight | at corrected age 6 months and 18 months | Computed according to the WHO standards (2006) |
| Percentage of infants who achieve catch-up growth | at corrected age 6 months and 18 months | Catch-up growth is defined as weight, length/height or head circumference equal to or above the 25th percentile for corrected age, according to the WHO standards (2006). |
| Body fat free mass | at corrected age 40 gestational weeks and 6 months | assessed by air displacement plethysmography (ADP) |
| Z-scores of length/height | at corrected age 40 gestational weeks | Computed according to the Fenton preterm growth standards (2013) |
| Body fat proportion | at corrected age 40 gestational weeks and 6 months | assessed by air displacement plethysmography (ADP) |
| Cognitive development outcome | at corrected age 18 months | It is examined by six areas of development measured by Griffith Mental Development Scales (GMDS) including locomotor, personal-social, hearing and language, eye and hand co-ordination, performance and practical reasoning. Developmental impairment is defined as a developmental quotient lying one standard deviation below the mean (\<85) and includes mild impairments (70-84) and moderate/severe impairment (\<70). |
| Intestinal flora change | from birth to corrected age 18 months | The change of composition of intestinal flora in preterm infants. The composition of intestinal flora was test by 16s rRNA sequencing. |
| Body fat mass | at corrected age 40 gestational weeks and 6 months | assessed by air displacement plethysmography (ADP) |
Countries
China
Outcome results
None listed