Neurocognitive Disorders
Conditions
Keywords
Cognition, motivation, technology, non pharmacological intervention
Brief summary
Memory, attentional, and behavioural symptoms are the clinical hallmarks of Neurocognitive disorders (NCD) such as Alzheimer's disease and related disorders. The World Health Organisation (WHO) guidelines for risk reduction of cognitive decline and dementia indicate that Cognitive training may be offered to older adults with normal cognition and with mild cognitive impairment to reduce the risk of cognitive decline and/or dementia. The use of Information and Communication Technologies (ICT) in the health domain is progressively expanding. The Alzheimer Innovation Association have developed MeMo (Memory Motivation) a free web application that can be used at home by patients. The objective of the present study was to assess the effectiveness of employing the MeMo platform on cognitive performance in patients suffering from NCD.
Detailed description
The objective of this study is to evaluate the effectiveness of the MeMo cognitive training exercise platform in patients suffering from neurocognitive disorders. These exercises ,have been developed by the association Innovation Alzheimer and the CoBTeK research team, located with the Nice memory Center at the Institut Claude Pompidou. MeMo can be used freely at home by patients. More specifically, it is a randomized controlled study that aims to compare the evolution of activities cognition and behavior between patients not using these exercises, and patients using these exercises for 12 weeks, 4 sessions per week.
Interventions
DEVICEMeMo web application
The patient betwenn 2 consultation could use the application MeMo. MeMo is a web application that can thus be used on any web browser (computer or tablet). On tablet, the application can be installed on home screen to look like a native app, and used offline.
OTHERControl group
the patient have the classical follow up at the memory center (consultation)
Sponsors
Alzheimer's Association
Centre Hospitalier Universitaire de Nice
Université de Nice Sophia Antipolis
Innovation Alzheimer
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Masking description
Randomization for the allocation of the patient in each group
Intervention model description
regular use of a web application at home to train cognition and behavior
Eligibility
Sex/Gender
ALL
Age
60 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Outpatient consulting the Memory center * older than 60 years old * Mini Mental State examination score (MMSE) between 16 and 28 / 30 * met the DSM 5 diagnoses of mild neurocognitive disorders (mild NCD) or major neurocognitive disorders (Major NCD).
Exclusion criteria
* Patients not able to read and write French * presence of a hearing or major visual impairment * a history of premorbid mental retardation * had already used the MeMo application * were presently involved in structured memory training activities.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change is being assessed with the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) | Base line, Week 12 | To score the IQCODE, add up the score for each question and divide by the number of questions. For the long IQCODE, divide by 26. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in attention is is being assessed with the DSST | Base line, Week 12 | Digit Symbol Substitution Test (attentional task) |
| Change in frontal functioning is being assessed with the FAB | Base line, Week 12 | the Frontal Assessment Battery: Score 0 (healthy) - 18 (pathology) |
| Change in behavior is being assessed with the NPI | Base line, Week 12 | Neuropsychiatric Inventory score 0 (healthy) - 134 (pathology) |
| IA-C | Base line, Week 12 | Change in motivation is being assessed with theApathy inventory, clinician version score 0 (healthy)- 12 (pathology) |
Countries
France
Outcome results
None listed