Spinal Anesthesia, Autonomic Nervous System
Conditions
Keywords
spinal anesthesia, autonomic nervous system, dexmedetomidine, propofol
Brief summary
Spinal anesthesia induces bradycardia and hypotnesion, because itself decreases parasympathetic activity and increases sympathetic activity. These imbalance of autonomic nervous system can be measured by heart rate variability. Propofol and dexmedetomidine, which are used for sedation during spinal anesthesia, also affect autonomic nervous system, but the exact effects are not well known. The purpose of this study is measuring the effects of propofol or dexmedetomidine on autonomic nervous system in spinal anesthesia.
Detailed description
Spinal anesthesia induces bradycardia and hypotnesion, because itself decreases parasympathetic activity and increases sympathetic activity. These imbalance of autonomic nervous system can be measured by heart rate variability. Propofol and dexmedetomidine, which are used for sedation during spinal anesthesia, also affect autonomic nervous system but the exact effects are not well known. Moreoever, the effect of spinal anesthesia combined with sedation agent on autonomic nervous system has not been evaluated. The purpose of this study is measuring the effects of propofol or dexmedetomidine on autonomic nervous system in spinal anesthesia. The current study is prospective randomized pilot study. Patients are assigned to propofol group and dexmedetomidine group. Using electrocardiaogram analysis, the change of autonomic nervous system will be measured from preoperative to end of surgery.
Interventions
DRUGDexmedetomidin
Dexmedetomidine as a sedation drug
DRUGPropofol
Propofol as a sedation drug
Sponsors
Ilsung Pharmaceuticals CO.,LTD.
Ajou University School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Intervention model description
Propofol group: propofol infusion as sedation drug Dexmedetomidine group: dexmedetomidine infusion as sedation drug
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* age 20\ 60 years old * Scheduled lower extremity surgery under spinal anesthesia
Exclusion criteria
* Arryhthmia * Uncooperative patients * Diabetes * On medication: beta blocker, psychiatric medicine * Thyroid function abnormality
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serial heart rate variability | 40 minutes (before entering the operating room ~ 20 minutes after starting sedation | Serial change of frequency domain results from EKG RR interval Baseline: before entering the operating room T0: Preinduction T1: 10 minutes after spinal anesthesia T2: 10 minutes after starting sedation T3: 20 minutes after starting sedationi Frequency domain results Total power (ms2) Low frequency (ms2) High frequency (ms2) LF/HF ratio |
Countries
South Korea
Outcome results
None listed