Blood Pressure, Preeclampsia and Eclampsia, Stiffness, Aortic
Conditions
Keywords
Preelampsia, Cardio-ankle vascular index (CAVI), Aortic stiffness, Blood pressure, LDL-cholesterol
Brief summary
The investigator measured the arterial stiffness using cardio-ankle vascular index (CAVI) test in patient with preeclampsia and normal pregnant women to evaluate the longitudinal change of CAVI and their predictors.
Detailed description
This study was a case control study and included 37 women with preeclampsia (PE group) and 36 normotensive women (control group) who gave birth to child at Seoul National University Bundang Hospital. Cario-ankle vasuclar index (CAVI) was measured at one day, six months and one year after delivery in both group. The investigator also checked the body weight, blood pressure, lipid profile, serum creatinine, aspartate transaminase (AST) and alanine transaminase (ALT) simultaneously with CAVI. The relationship between the presence of preelampsia and longitudinal changes of CAVI, blood pressure and metabolic indices were evaluated using generalized estimating equation (GEE) method.
Interventions
None listed
Sponsors
Seoul National University Bundang Hospital
Seoul National University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
1. Case group : Women who were diagnosed preeclampsia based on the criteria of the International Society for the Study of Hypertension in Pregnancy 2. Control group : Normotensive women who gave birth to child at Seoul National University Bundang Hospital.
Exclusion criteria
* Women who were hemodynamically compromised or had bleeding complication after delivery were excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The differences in longitudinal change pattern of CAVI between preeclampsia and normal pregnant women. | The CAVI was measured at one day, six months and one year after delivery in both groups. | The CAVI was analyzed with generalized estimating equation (GEE) method to evaluate the different change pattern of CAVI between two groups. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Body weight | one day, six months and one year after delivery | kilograms |
| Systolic blood pressure | one day, six months and one year after delivery | automated blood pressure, mmHg |
| Waist/Hip ratio | one day, six months and one year after delivery | Waist circumference in centimeter, Hip circumference in centimeter, Waist/Hip Circumference Ratio is the ratio of waist circumference divided by hip circumference |
| Diastolic blood pressure | one day, six months and one year after delivery | automated blood pressure, mmHg |
| AST(aspartate aminotransferase), ALT(alanine aminotransferase) | one day, six months and one year after delivery | IU/L (International Units Per Litre) |
| Serum creatinine | one day, six months and one year after delivery | mg/dL (milligrams per deciliter) |
| Lipid profiles (Total cholesterol, TG, LDL, HDL) | one day, six months and one year after delivery | mg/dL (milligrams per deciliter) |
Countries
South Korea
Outcome results
None listed