HIV, HIV Infections
Conditions
Brief summary
The investigators are studying whether metabolic abnormalities in calf (leg) muscle in older people with and others without HIV are associated with decreased abilities to exercise.
Detailed description
This research is being done to better understand why some older people living with HIV experience more fatigue and difficulty exercising than older people without HIV. This is important because fatigue and problems exercising are predictors of disability and hospitalization in older individuals. We will use non-invasive magnetic resonance imaging (MRI) and spectroscopy (MRS) of the leg muscle to measure muscle metabolites and fat content, as well as blood samples measures levels of inflammation.
Interventions
None listed
Sponsors
Johns Hopkins University
National Institute on Aging (NIA)
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
60 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* Participants who are \>= 60 years of age * HIV serostatus positive participants on stable antiretroviral therapy (ART) (no regimen change in last month) with undetectable HIV viral load (\<100 copies). * HIV serostatus negative participants
Exclusion criteria
* Unable to understand the risks, benefits, and alternatives of participation and give meaningful consent * Contraindications to MRI * Significant cardiovascular, pulmonary or musculoskeletal or orthopedic disease that significantly limits exercise capacity * Significant lower extremity peripheral vascular disease. * Weight greater than 350 lbs * Cognitive or speech impairments that would limit completion of questionnaires or fatigue reporting.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maximal mitochondrial oxidative capacity (VmaxPCr) | Baseline | Maximal oxidative capacity of leg muscle measured by 31P Magnetic Resonance Spectroscopy (MRS) |
| Rate of PCr decline during plantar flexion exercise | Baseline | — |
| Six minute walk distance | Baseline | — |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Skeletal muscle fat content | Baseline | — |
| Gait speed | Baseline | — |
| Frailty status (as measured by the Fried Frailty Index) | Baseline | Fried frailty index described in J Gerontol A bill Sci-Fi Med Sci-Fi 2001;56:M146-56 |
Countries
United States
Contacts
CONTACTMaria Esteban, RN, BSN
CONTACTTricia Steinberg, RN, MSN
PRINCIPAL_INVESTIGATORRobert G Weiss, MD
Johns Hopkins University
Outcome results
None listed