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Age-Related Changes in Sleep-Dependent Emotional Memory

AGE-RELATED CHANGES IN SLEEP-DEPENDENT EMOTIONAL MEMORY

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04141722
Enrollment
80
Registered
2019-10-28
Start date
2018-12-11
Completion date
2020-05-31
Last updated
2019-10-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Age, Emotional Valence, Sleep

Keywords

Emotional Memory, Memory Consolidation, Age-Related Positivity Effect

Brief summary

Memory influences emotional well being. Research has shown that having a negative emotional bias contributes to both emotion dysregulation and depression. Conversely, reactivating positive memories has been shown to reduce stress and symptoms of depression. In young adults, sleep is widely implicated in emotional processing, including consolidation of emotional memories. Evidence suggests that aging is associated with changes in emotion, including a positive memory bias and enhanced emotional well-being. These changes have been termed the age-related positivity effect. However, the influence of sleep on these measures has not been investigated in healthy older individuals. The objective of this research is to understand the role of sleep in emotional memory consolidation and emotional well-being across adulthood. We hypothesize that sleep contributes to the age-related positivity effect in memory and affect. Our alternative hypothesis is that age-related decreases in sleep are responsible for reduced emotional memory processing over healthy aging.

Interventions

BEHAVIORALOvernight sleep

Participant sent home to sleep overnight wearing PSG.

BEHAVIORALWake

Participant sent to go about normal daily routine, instructed not to nap, drink caffeine, or engage in strenuous exercise.

Sponsors

University of Massachusetts, Amherst
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes

Inclusion criteria

* 18-30 or 50-80 years of age * Have no history of a sleep disorder * Have no history of neurological disease or injury * Have no history of psychiatric illness (anxiety or mood disorder, schizophrenia, etc.) * No history of chemotherapy * Not be taking medications which effect sleep * Habitually sleep more than 6 or more hours per night * Be able to walk freely and independently * Have normal to corrected-to-normal vision

Design outcomes

Primary

MeasureTime frameDescription
Memory bias12 hr delay between encoding and recognition testCorrected recognition of positive versus negative pictures

Countries

United States

Contacts

Primary ContactRebecca Spencer
rspencer@psych.umass.edu(413) 545-5987

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026