Venous Thromboembolism (VTE)
Conditions
Brief summary
A study involving real-world database analysis to evaluate the hospital healthcare utilization and costs, and all-cause, major bleeding-, clinically relevant bleeding-, any bleeding-, and venous thromboembolism (VTE)-related hospital readmissions among hospitalized VTE patients treated with apixaban or warfarin, with or without low molecular weight heparin (LMWH)
Interventions
None listed
Sponsors
Bristol-Myers Squibb
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Have a primary diagnosis of VTE identified by ICD-9-CM or ICD-10 codes from the Premier Hospital database between 01-Aug-2014 and 31-May-2016 * Age 18 years or older as of index hospitalization with VTE diagnosis * Patients will be required to have received apixaban or warfarin with or without LMWH (index drugs) during the index hospitalizations
Exclusion criteria
* Received both apixaban and warfarin during the index hospitalization. This exclusion criterion will allow to cleanly group patients into the apixaban and warfarin usage cohorts. * Received any other Direct oral anticoagulants (DOAC) including rivaroxaban, dabigatran, and edoxaban during the index hospitalization * Have any primary or secondary diagnosis code for Atrial fibrillation/Atrial flutter (AF/AFL), or pregnancy, or records of inferior vena cava filter (IVCF) usage during the index hospitalizations or the baseline periods. * Patients transferred from other facilities Other protocol-defined inclusion/
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hospital Length of stay (LOS) | During the index hospitalization (Up to 30 days) |
| Hospital cost | During the index hospitalization (Up to 30 days) |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of patients with clinically relevant bleeding (CRB)-related hospital readmissions | During 1 month after the index hospitalization |
| Proportion of patients with any bleeding-related hospital readmissions | During 1 month after the index hospitalization |
| Proportion of patients with VTE-related hospital readmissions | During 1 month after the index hospitalization |
| Proportion of patients with combined VTE- or MB-related hospital readmissions | During 1 month after the index hospitalization |
| Proportion of patients with all-cause hospital readmissions | During 1 month after the index hospitalization |
| Hospital Length of stay (LOS) for major bleeding-related hospital readmissions | During 1 month following the VTE hospitalization |
| Hospital costs of readmissions for major bleeding-related hospital readmissions | During 1 month following the VTE hospitalization |
| Hospital charges of readmissions for major bleeding-related hospital readmissions | During 1 month following the VTE hospitalization] |
| Mean number of hospital readmissions for major bleeding-related hospital readmissions | During 1 month following the VTE hospitalization |
| Hospital LOS for clinically relevant bleeding-related hospital readmissions | During 1 month following the VTE hospitalization |
| Hospital costs of readmissions for clinically relevant bleeding-related hospital readmissions | During 1 month following the VTE hospitalization |
| Hospital charges of readmissions for clinically relevant bleeding-related hospital readmissions | During 1 month following the VTE hospitalization |
| Mean number of hospital readmissions for clinically relevant bleeding-related hospital readmissions | During 1 month following the VTE hospitalization |
| Hospital LOS for any bleeding-related hospital readmissions | During 1 month following the VTE hospitalization |
| Hospital costs of readmissions for VTE-related hospital readmissions | During 1 month following the VTE hospitalization |
| Hospital charges of readmissions for any bleeding-related hospital readmissions | During 1 month following the VTE hospitalization |
| Mean number of hospital readmissions for any bleeding-related hospital readmissions | During 1 month following the VTE hospitalization |
| Hospital LOS for VTE-related hospital readmissions | During 1 month following the VTE hospitalization |
| Hospital charges of readmissions for VTE-related hospital readmissions | During 1 month following the VTE hospitalization |
| Mean number of hospital readmissions for VTE-related hospital readmissions | During 1 month following the VTE hospitalization |
| Hospital LOS for combined VTE- or MB-related hospital readmissions | During 1 month following the VTE hospitalization |
| Hospital costs of readmissions for combined VTE- or MB-related hospital readmissions | During 1 month following the VTE hospitalization |
| Hospital charges of readmissions for combined VTE- or MB-related hospital readmissions | During 1 month following the VTE hospitalization |
| Mean number of hospital readmissions for combined VTE- or MB-related hospital readmissions | During 1 month following the VTE hospitalization |
| Hospital LOS for all-cause hospital readmissions | During 1 month following the VTE hospitalization |
| Hospital costs of readmissions for all-cause hospital readmissions | During 1 month following the VTE hospitalization |
| Hospital charges of readmissions for all-cause hospital readmissions | During 1 month following the VTE hospitalization |
| Mean number of hospital readmissions for all-cause hospital readmissions | During 1 month following the VTE hospitalization |
| Hospital costs of readmissions for any bleeding-related hospital readmissions | During 1 month following the VTE hospitalization |
| Proportion of patients with major bleeding (MB)-related hospital readmissions | During 1 month after the index hospitalization |
Countries
United States
Outcome results
None listed