Chronic Respiratory Disease, COPD, Interstitial Lung Disease
Conditions
Keywords
pulseoxymetry, capnography, Dead space, cardiac output, lung recruitment, deep breaths
Brief summary
This is a study designed to measure, characterize and describe changes on pulse-oxymetry values produced as a result of deep breaths in patients with stable chronic hypoxemic respiratory failure.
Detailed description
There is no standard way of measuring rest pulse-oxymetry in terms of depth of respiration. Rest pulse-oxymetry values are used in the clinical setting to make therapeutic decisions regarding the need of supplemental oxygen. The primary goal of this study is to measure the change of pulse-oxymetry values during an experimental protocol of 10 deep breaths during one minute in patients with chronic hypoxemia. 45 patients will be studied in this first phase. In a second phase, secondary goals will be to measure Vd/Vt vent, noninvasive cardiac output and CT densitometry during the same deep breaths protocol in a subset of 13 patients with the grater increase observed in the first phase of study.
Interventions
PROCEDUREDeep breaths
Patients will undergo a 6 minutes protocol. Baseline: 1 minute normal breaths. Intervention: 1 minute with 10 deep breaths, 1 each 6 secs. Pulse-oxymetry will be continuously recorded.
Sponsors
Universidad Autonoma de Nuevo Leon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Intervention model description
Clinical experimental trial of changes in pulse-oxymetry measurements with deep inspirations
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with chronic lung disease causing rest hypoxemia, with rest SpO2 values equal or lower than 94% on room air * Ambulatory patients capable of performing 6 min walking test * Patients older than 18 years old.
Exclusion criteria
* Patients with significant collagen disease causing Raynaud phenomenon. * Patients with hypothermia lower than 35 degrees Celsius * Patients with rest SpO2 values equal or lower than 80% on room air * Patients unable to perform PFTs * Patients unable to complete 6 min walking test without supp O2. * Patients unable to perform experimental deep breaths on CT scan
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in O2 saturation | Lenght of experimental protocol: 6 minutes. | A Saturation change greater than 4% will be considered significant |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| CT recruitment | Lenght of experimental protocol: 6 minutes. | In a subset of 13 patients with the greater increase on O2Sat, CT recruitment will be calculated using densitometry values during the same protocol |
| Vd/VT | Lenght of experimental protocol: 6 minutes. | In a subset of 13 patients with the greater increase on O2Sat, Vd/Vt will be measured during the same protocol |
| Cardiac output (CO) | Lenght of experimental protocol: 6 minutes. | In a subset of 13 patients with the greater increase on O2Sat, CO will be measured during the same protocol |
Countries
Mexico
Contacts
Primary ContactUriel Chavarria, MD
Outcome results
None listed