Transcranial Direct Current Stimulation (tDCS) Combined With Computerized Cognitive Addiction Therapy(CCAT) and, Electronic Follow-up for Methamphetamine(MA) Dependent Patients

Study on the Effectiveness of Treatment Regulation Mode Based on Neuromodulation and Electronic Follow-up to Reduce Relapse Behavior in Patients With Substance Dependence

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04139148

Enrollment

100

Registered

2019-10-25

Start date

2019-02-01

Completion date

2021-12-31

Last updated

2019-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Computerized Cognitive AddictionTherapy, Electronic Health Records, Methamphetamine-dependence, Transcranial Direct Current Stimulation

Brief summary

Transcranial direct current stimulation (tDCS) combined with computerized cognitive addiction therapy(CCAT) for methamphetamine(MA) dependent patients in voluntary drug rehabilitation center. Electronic medical systems were applied for drug related knowledge education, self-evaluation and outpatient follow-up reminder after intervention in order to reduce relapse behaviors.

Interventions

DEVICETure Transcranial Direct Current Stimulation (tDCS)

Ture 1-2 mA current of tDCS intervention in patients' binary brain DLPFC areas(20 mm).

DEVICESham Transcranial Direct Current Stimulation (tDCS)

Sham tDCS intervention in patients' binary brain DLPFC areas(20 mm).

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Methamphetamine dependent patients with normal eyesight and hearing.

Exclusion criteria

* any diagnosis of DSM-IV axis I diseases. * any physical diseases which might influence cognitive function such as epilepsy, cerebrovascular disease or brain injury. * negative behaviors or harm to others. * cognitive enhance drug use history in last 6 months. * other drug dependence(except nicotine).

Design outcomes

Primary

Measure	Time frame	Description
Change from Baseline cue-induced craving at 2 weeks	2 weeks	Participants were instructed to watch methamphetamine-related videos by VR and rate their level of craving after smelling and recalling the last time they engaged in drug use. Craving was assessed by visual analog scales (VAS), with 0 mm being no cravingand 100 mm representing most craving ever experienced for methamphetamine.
Change from Baseline cue-induced craving at 4 weeks	4 weeks	Participants were instructed to watch methamphetamine-related videos by VR and rate their level of craving after smelling and recalling the last time they engaged in drug use. Craving was assessed by visual analog scales (VAS), with 0 mm being no cravingand 100 mm representing most craving ever experienced for methamphetamine.

Secondary

Measure	Time frame	Description
Attention bias towards methamphetamine	2 weeks，4 weeks	A Chinese version of the MA addiction dot probe task (DPT) is used to evaluate the attention bias towards drugs.
cognitive function	2 weeks，4 weeks	Chinese version of the CogState Battery was used to assess cognitive function.
response inhibition function	2 weeks，4 weeks	stop signal task
reward-related function	2 weeks，4 weeks	Delay Discounting Task

Countries

China

Contacts

Primary ContactNa Zhong, Doctor, doctor

winco917@hotmail.com008613671644472

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026