Genetic Susceptibility to Radiation Induced Thyroid Cancer

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04139096

Enrollment

Registered

2019-10-25

Start date

2019-09-22

Completion date

2021-09-22

Last updated

2026-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Genetic Susceptibility, Radiation Exposure, Thyroid Neoplasms

Brief summary

Case control on thyroid cancer occuring in a cohort of 7300 subjects treated during their childhood, mostly by radiotherapy, for a skin Angioma at Gustave Roussy, Villejuif France between 1947 and 1973. This case control study, which is included in a larger european project, aims to investigate the DNA variant interacting with the risk of radiation induced thyroid cancer after irradiation. The sutdy is planed to include about 30 cases and 30 controls. Matching criteria are date of birth, gender, and age at irradiation.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Diganosis of thyroid cancer during the followup or selected as a control matched on gender, date of birth and age at skin hemangioma diagnosis.

Exclusion criteria

No available adress Refusal

Design outcomes

Primary

Measure	Time frame	Description
Number of Differentiated thyroid carcinoma	From hemangioma diagnosis to the end of the followup, in average 45 years after hemangioma diagnosis	Number of differentiated thyroid carcinoma occuring in a cohort of subjects treated for a skin hemangioma during the follow-up

Countries

France

Contacts

PRINCIPAL_INVESTIGATORFlorent de Vathaire, PhD

Institut National de la Santé Et de la Recherche Médicale, France

Outcome results