Acromegaly, Olfactory Disorder
Conditions
Keywords
Acromegaly, Olfaction, Olfactory disorder
Brief summary
A prospective, controlled, single blinded study was planned. 20 patients with Acromegaly (Acromegaly Group) and 20 healthy subjects (Control Group) were planned to include in the study. Connecticut Chemosensory Clinical Research Center (CCCRC) test was applied to evaluate olfactory functions. Olfactory bulb(OB) volumes were measured with a 1.5 T General Electric Signa Excite MRI scanner.
Detailed description
Acromegaly patients were assessed at the Endocrinology Department for their clinical symptoms, and the nasal examination and olfactory evaluation were done at the Department of Otorhinolaryngology. OB volume was evaluated by a single blinded radiologist. Control group patients that had similar demographical characteristics with the Acromegaly Group were recruited in the study. The CCCRC test is composed of n-butanol odor threshold test and odor identification test. Olfactory tests were scored out of 7 (0: worst, 7: best olfaction) and mean score was calculated as the total CCCRC test score. OB measurements were done individually on the right and left olfactory bulbs and the mean OB volume was calculated in cubic millimeters.
Interventions
OTHEROB volume
The mean OB volume was calculated in cubic millimeters and compared between the two groups.
OTHERCCCRC test
CCCRC test was done for olfactory function assessment and compared between the two groups.
Sponsors
Bezmialem Vakif University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Investigator)
Masking description
OB measurements were done in a single-blinded method.
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Acromegaly diagnosis * Healthy subjects that had no nasal problems
Exclusion criteria
* Previous nasal surgery * Acute respiratory tract infection * Nasal polyposis * Nasal pathologies that causes nasal obstruction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Olfactory bulb (OB) volume | 18 months | Measurements were done individually on the right and left OB, and the mean OB volume was calculated in cubic millimeters. The mean OB volume was compared between the two groups. |
| CCCRC test results | 18 months | Olfactory tests were scored out of 7 (0: worst, 7: best olfaction) and mean score was calculated as the total CCCRC test score. The mean score was compared between the two groups. |
Countries
Turkey (Türkiye)
Outcome results
None listed