Laparoscopic Cholecystectomy
Conditions
Keywords
Dexmedetomidine, Fentanyl, Lignocaine, Laryngoscopy, Hemodynamic Response, Laparoscopic Cholecystectomy
Brief summary
Comparison Of Dexmedetomidine, Fentanyl And Lignocaine In Attenuation Of Hemodynamic Response To Direct Laryngoscopy And Intubation In Patient Undergoing Laparoscopic Cholecystectomy
Detailed description
Direct laryngoscopy and intubation are painful stimulus that activates sympathoadrenal discharge which results in intense cardiovascular reflex i.e. tachycardia and hypertension. In this study we will compare effects of intravenous dexmedetomidine, fentanyl and lidocaine for attenuation of these reflexes in patient undergoing laproscopic cholecystectomy. how these agents will effect hemodynamic response during pneumoperitoneum. Tertiary objective will be to observe sedation, perioperative complications and recovery in these patients.
Interventions
DRUGdexmedetomidine
intravenous dexmedetomidine 0.06mg/kg in 100ml normal saline 0.9% over 10minutes.
DRUGfentanyl
intravenous fentanyl at 2mcg/kg in 100ml saline over 10 minutes in induction room.
DRUGlidocaine
intravenous lidocaine 1.5mg/kg in 100ml saline over 10 minutes in induction room.
Sponsors
Dow University of Health Sciences
Sana Urooj
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Masking description
Patients do not know about the interventions.
Intervention model description
Randomized control trial
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* ASA-I and ll patients * Male and female patient of age 20-70 years. * Undergoing Elective surgery * Intubation by skilled anesthetist of at least 2 years' experience * Intubation not more than 45 seconds
Exclusion criteria
* Patients with uncontrolled DM, HTN, IHD, endocrine or autonomic dysfunction * Pregnant and lactating females * Short thick neck with anticipated difficult intubation * Any sort of obstructive restrictive or reactive airway disease * Patient allergic to any of the study medications. * Obese patients, Narcotic addicts
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Heart rate | at induction | Hemodynamic responses (average heart rate beats a minute) |
| systolic blood pressure | at induction | hermodynamic response (Top number will be assessed of blood pressure) |
| Diastolic blood pressure | at induction | hermodynamic response (bottom number will be assessed of blood pressure) |
| mean atrial pressure | at induction | Hemodynamic responses (average blood pressure in an individual during a single cardiac cycle) |
| Oxygen saturation (SpO2) | at induction | Hemodynamic responses) (arterial oxy-hemoglobin saturation is measured non-invasively by a finger pulse oximeter or handheld pulse oximeter, |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Recovery assessment | at 10 minutes post operatively | Aldret score use for recovery assessment, it consist of 0-10 point where 0 indicates worst(no response) and 10 indicates good response |
| Complications | 1 week Post-operative(Operation -discharge) | Cough, Laryngospasm, Bradycardia, Regugitation, PONV, Hypertention, Hypotension |
| Sedation assessment | at 10 minutes post operative | Ramsey score use for sedation, it consist of 1-6 where 6 indicates worst(no response) and 6 indicates good response |
Countries
Pakistan
Contacts
Primary ContactSana Urooj, FCPS
Backup ContactSana Urooj
Outcome results
None listed