Spermatic Cord Torsion, Testicular Torsion
Conditions
Keywords
Fertility, Testicular Torsion, Testicular function
Brief summary
The purpose of this study is to evaluate testicular function measured as testosterone level and semen quality.
Detailed description
Men having undergone surgery for testicular torsion between 01.01.2003 - 12.31.2012 will receive a invitation to participate in this study. It is expected that 110 patients can be identified and about 65% of them will participate. These men will undergo a andrological evaluation, deliver a semen sample, have a blood sample taken and undergo a testicular ultrasound. Control group: Men attending the fertility counseling at Herlev hospital will be offered participation in this study. The fertility counseling demands that men who contact the clinic have never had their sperm analyzed, have not tried to get pregnant with their partner for more than a year and that they have no prior knowledge of their fertility. Primary endpoint: * Semen quality measured as sperm concentration * Total testosterone level Secondary endpoint: Semen parameters * Semen volume (ml) * Sperm concentration (x 106/ml) * Sperm motility (%) (både klasse AB og ABC) * sperm morphology * IgA-bound spermatozoa (%) * IgG-bound spermatozoa (%) Hormones * FSH * LH * PRL * Testosterone * Estradiol * Inhibin B * Insulin-like peptide 3 * SHBG Data points: * Paternity * Time to pregnancy * Partner (yes/no) * Any fertility treatment? * Pain? (VAS score) * Symptoms of testesterone deficiency symptoms * Andrological evaluation * Testicular ultrasound * Testicular torsion events in the family * Date of surgery * Date of follow up meeting * Surgery details
Interventions
None listed
Sponsors
Herlev and Gentofte Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Men with a verified testicular torsion operated at Herlev and Gentofte hospital between 01.01.2003 and 12.31.2012
Exclusion criteria
* Retentio testis * Varicocele * Previous treatment with chemo- or radiation therapy * Genetic disposition for infertility * Anejculation * Retrograde ejaculation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sperm concentration | 8-17 years after surgical intervention | Amount of motile sperm cells (\* 10\^6) |
| Testosterone level | 8-17 years after surgical intervention | ng/ml |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| MAR test result correlated to the type of surgery | 8-17 years after surgical intervention | MAR test of sperm cells |
| Semen parameters as an indicator of overall testicular exocrine function | 8-17 years after surgical intervention | Compared with results from control group |
| Paternity as a measure of fertility | 8-17 years after surgical intervention | Number of kids if any. |
| Difference in sperm morphology and motility correlated to the type of surgery and compared to control group | 8-17 years after surgical intervention | Morphology and motility (%) |
| Hormone level as an indicator of testicular endocrine function | 8-17 years after surgical intervention | Follicle stimulating hormone, luteinizing hormone, prolactin, testosterone, estradiol, inhibin B, sex hormone-binding globulin, albumin |
Countries
Denmark
Contacts
Primary ContactFrederik M Jacobsen
Backup ContactTrine Møller Rudlang, MD
Outcome results
None listed