Disorder of Consciousness, Minimally Conscious State, Unresponsive Wakefulness Syndrome
Conditions
Keywords
disorders of consciousness, unresponsive wakefulness syndrome, minimally conscious state, Nociception Coma Scale-Revised
Brief summary
The aim of this study was to investigate the relationship between behaviorally assessed consciousness levels and responsiveness to nociception in patients with disorders of consciousness (DOC)
Detailed description
Patients with a clinical consensus of DOC were enrolled. The Coma Recovery Scale-Revised (CRS-R) was used to assess the DOC patients' consciousness levels and the Nociception Coma Scale-Revised (NCS-R) was used to evaluate their pain response over one week. Furthermore, the relationship between behaviorally assessed consciousness levels and pain response was analyzed.
Interventions
DIAGNOSTIC_TESTThe Coma Recovery Scale-Revised and the Nociception Coma Scale-Revised (NCS-R)
All enrolled DOC patients were evaluated at least five times over one week by two trained professionals using the Chinese version of the CRS-R. During the evaluation of the patient's consciousness level, the NCS-R was used to evaluate the pain response of all patients in random order at least once, and the best behavioral response (i.e., the highest score) of each subscale was recorded during resting, noxious, and physiotherapy conditions, respectively, according to the NCS-R guidelines.
Sponsors
Hangzhou Normal University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
20 Years to 84 Years
Healthy volunteers
No
Inclusion criteria
* (1) at least 18 years old * (2) acquired brain injury * (3) no neuromuscular blockers or sedatives used within 72 hours of enrollment.
Exclusion criteria
* (1) functional disorders caused by progressive mental diseases * (2) persistent seizures * (3) unstable vital signs * and/or (4) double upper-limb frustration, fracture.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Nociception Coma Scale-Revised | Within 7 days | The Nociception Coma Scale-Revised was used to evaluate the pain response of all patients in random order at least once. A score greater than or equal to 3 points indicated that the patient was responsive to pain stimulation, while a score greater than or equal to 4 points suggested that the patient might have pain perception related to consciousness. |
Countries
China
Outcome results
None listed