Dental Caries
Conditions
Brief summary
Prevention of dental caries has taken a great importance in the last decade. The use of herbal and natural products became mandatory to avoid the side effects of commercially available medications. Aim of the study; the aim was to investigate the anti-cariogenic effect of miswak and grape seed extract (GSE).
Detailed description
Patients used Miswak sticks, grape seed extract mouth wash and fluoride mouthwash twice daily for three month. Saliva samples were collected at base line and after one month and three month. Assessment of bacterial count and saliva buffering capacity were performed at base line and after one and three month.
Interventions
Sponsors
Al-Azhar University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients with high caries risk * Males or females * Medically free patients * Patients approving to participate in the study
Exclusion criteria
* Patients who were on antibiotic therapy or corticosteroid therapy for 30 days before the examination * Patients had history of professional cleaning in the last 15 days * Patients with exposed pulp * Evidence of parafunctional habits * Patients with developmental dental anomalies * Patients undergoing or will start orthodontic treatment * Patients with removable prosthesis * Periapical Abscess or Fistula
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| quantitative measure of the change in salivary streptococcus mutans Count from baseline to one month and three months. | Baseline, one month, three months. | the patients used the treatments twice daily for three months. unstimulated saliva samples were collected from the patients at baseline,after one month and after three months. Every time samples were incubated with Mitiis Salivaris with Bacitricin and 20% sucrose for streptococcus mutans count. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| quantitative measure of the change in saliva buffering capacity from baseline to one month and three months. | baseline, one month , three months | the patients used the treatments twice daily for three months. unstimulated saliva samples were collected from the patients at baseline, after one month and after three months. each time, saliva buffering capacity was measured using Hand Held pH meter and 0.1 mol/l hydrochloric acid that was titrated to the tested saliva. |
Countries
Egypt
Outcome results
None listed