Graves Disease
Conditions
Keywords
Atuoimmune thyroid disease, Graves' disease, Natural killer cell
Brief summary
Graves' disease (GD) is one of organ specific autoimmune diseases, the pathogenesis is not elucidated.Natural Killer (Natural Killer, NK) cells is a kind of important immune regulator, several abnormalities of NK cell function and number in GD patients have been described in the investigators' previous study. It is remain unclear whether the NK cell disfunction is a consequence of GD.Based on the investigators' previous study, the investigators plan to monitor NK cell function in participants in the whole course of disease, analyze the association with relevant factors, such as thyroid function, immune state or treatment,to find out influences of thyroid hormones and thyroid receptor antibody affecting the function of NK cell. The investigators will reveal whether the disfunction of NK cell secondary to GD abnormal thyroid function and/or immune disorders, and realize the mechanics.
Interventions
None listed
Sponsors
Shandong Provincial Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* New GD patients without any treatment * Aged of 18 to 75 years old
Exclusion criteria
* Pregnant or lactating woman; * Known autoimmune disease; * Receiving psychotropic or hormonal drugs; * Taking drugs that affect the body's immune function; * Obviously poor compliance.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The number and function of NK cells changes of hyperthyroidism | measured after 2 years of follow-up | Flow cytometry used to measure the related changes of NK cells in hyperthyroidism |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in serum levels | measured after 2 years of follow-up | Detection of related cytokines by ELISA |
Countries
China
Outcome results
None listed