Optical Coherence Tomography Angiography in Myopic Patients

Evaluation of Macular Microvasculature in High Myopia Using Optical Coherence Tomography Angiography

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04135209

Enrollment

Registered

2019-10-22

Start date

2018-01-01

Completion date

2019-06-01

Last updated

2019-10-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myopia

Keywords

Optical coherence tomography, Angiography, Myopia

Brief summary

The aim of this study is to investigate the macular microvascular network alterations in high myopic eyes using optical coherence tomography angiography.

Detailed description

High myopia is defined as a refractive error equal to or more than -6 D, and/or axial length equal to or more than 25.5 mm².Axial elongation of the globe and subsequent stretch of the retina leads to sight threatening complications. Quantitative measurements of retinal vasculature in the healthy eye have been reported using several in vivo and in vitro techniques, including confocal microscopy, fluorescein angiography (FA), and swept-source optical coherence tomography (ssOCT) angiography. The aim of this study is to investigate the macular microvascular network alterations in high myopic eyes using optical coherence tomography angiography. This cross-sectional prospective study included 75 eyes of 54 patients, they were recruited from the outpatient clinic of ophthalmology department of El-Minia university hospital.They were divided into two groups, group A included 25 normal eyes of 25 patients. Group B included 50 myopic eyes of 30 patients. All patients subjected to history taking and full ophthalmological examination in addition to axial length measurment before performing OCTA.

Interventions

DIAGNOSTIC_TESTOptical coherence tomography angiography OCTA

Macular scanning using regular structural OCT as well as microvasculature analysis using OCTA

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* • Highly myopic subjects, defined as those with spherical equivalents (SEs) of -6 or more, with axial length greater than 26.5 mm. Group B individuals were chosen among healthy age-matched controls.

Exclusion criteria

* • Patients younger than 18 years old, or older than 45 years. * Any patient with macular pathology (e.g. diabetic retinopathy, hypertensive retinopathy, dystrophy) * Myopic patients with any vitro-retinal abnormalities (e.g. choroidal neovascular membrane (CNVM), foveoschisis,macular hole) * Patients who underwent previous intra ocular surgical procedures. * Patients with previous history of intraocular injections. * Glaucomatous patients.

Design outcomes

Primary

Measure	Time frame	Description
Difference in angiography between the 2 groups	through study completion, an average of 4 weeks	The difference of the volumetric data generated automatically from the OCTA machine at the 3 levels, (the inner retina, outer retina and the choriocapillaris) in three zones (the fovea, the parafovea and the whole image)

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026