Cognitive Dysfunction
Conditions
Brief summary
This clinical RCT study intends to combined different forms of multi-channel tDCS with the routine cognitive training process to treat patients with post-stroke cognitive dysfunction. The therapeutic effects among single-channel tDCS group, multi-channel tDCS and pseudo-multichannel tDCS group will be compared. Brain magnetic resonance mechanism research will also be included to reveal the possible mechanism of multi-channel tDCS technology for PSCI brain network. Thus, the efficacy and mechanism of multi-channel tDCS in post-stroke cognitive function rehabilitation will be researched both in the clinical and basic levels.
Interventions
DEVICEmulti-channel tDCS
multi-channel transcranial direct current stimulation, tDCS
DEVICEsingle-channel tDCS
single-channel transcranial direct current stimulation
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* 18-60 year-old * diagnosed cerebral apoplexy, meeting the diagnostic criteria of ICD-10 * cognitive function, perceptual function decline after stroke * first onset and duration of 3-12 months * right-handed * MMSE ≤25 * MoCA ≤25 * sign informed consent voluntarily and comply with the study plan
Exclusion criteria
* NIHSS ≥21 points * MoCA ≤18, or DRS-2 ≤ 124, or CES-D ≥ 16 * taking drugs that affect central nervous activity, such as nerve antagonists * specific contraindication, such as electrode patch allergy, local skin injury or - - - - inflammation, and hyperalgesia in stimulated areas * patients use implantable electronic devices (such as cardiac pacemakers) or have - metal implants such as stents that affect MRI examination * patients with a previous history of epilepsy, mental illness or skull injury * patients with dementia or obvious cognitive dysfunction before stroke * patients with aphasia or dysarthria and cannot complete the scale evaluation * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MMSE | Change from Baseline MMSE at 2 weeks and 3 months after intervention | Mini-mental State Examination |
| MoCA | Change from Baseline MoCA at 2 weeks and 3 months after intervention | Montreal Cognitive Assessment |
| AVLT | Change from Baseline AVLT at 2 weeks and 3 months after intervention | The Auditory-Verbal Learning Test |
| WAIS-DST | Change from Baseline WAIS-DST at 2 weeks and 3 months after intervention | WAIS Digit Symbol Test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| DEX | Change from Baseline DEX at 2 weeks and 3 months after intervention | Dysexecutive Ques-tionnaire |
| GNAT | Change from Baseline GNAT at 2 weeks and 3 months after intervention | Go/No-go Association Task |
Countries
China
Contacts
Primary ContactHongjie Jiang, Dr.
Outcome results
None listed