Blood Pressure, Neurovascular Control
Conditions
Keywords
Meal Timing, Blood Pressure, Time-Restricted Feeding, Sympathetic Nerve Activity
Brief summary
Brain blood flow, blood pressure, and neurovascular control mechanisms will be measured in middle-aged adults before and after a brief intervention period. The intervention will consist of changing the time in which the participant consumes food each day.
Detailed description
Healthy adults experience a 10-20% decrease in night-time blood pressure, compared with day-time blood pressure. However, 20-40% of middle-aged adults do not demonstrate a decrease in blood pressure. Abnormal blood pressure patterns are linked to sleep disturbances, hypertension, and associated with elevated cardiovascular risk and mortality. Additionally, abnormal diurnal blood pressure patterns are associated with impaired neurovascular control of the circulation, contributing to an increased risk of hypertension, stroke, and cardiovascular disease. Importantly, midlife is the critical period for implementing interventions to prevent or delay future cardiovascular disease. Recent data demonstrates that time-restricted feeding may normalize blood pressure patterns. The overall goal of this study is to determine if time-restricted feeding normalizes blood pressure patterns and improves neurovascular control. The research aims are: 1. To determine the effect of meal timing on blood pressure patterns in middle-aged adults. 2. To determine the effect of meal timing on neurovascular control in middle-aged adults.
Interventions
BEHAVIORALTime-Restricted Feeding
After baseline measurements have been completed, participants will enroll in a time-restricted feeding intervention. Participants will be asked to restrict the time in which they eat each day to 10 hours, fasting for the remaining 14 hours. Participants will also be asked to finish their last meal of the day at least 2 hours prior to bedtime.
Sponsors
American Heart Association
University of Wisconsin, Madison
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
The interventional study model used will consist of a time-restricted feeding intervention.
Eligibility
Sex/Gender
ALL
Age
50 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI ≤ 34 kg/m2 * Non-smoking * Sedentary or recreationally active * ≤ 2 Alcoholic drinks per day * Female subjects: Perimenopausal/Postmenopausal
Exclusion criteria
* History or evidence of hepatic, renal, hematological, peripheral vascular disease, or stroke/neurovascular disease, diabetes, uncontrolled hypertension, sleep apnea * On medications used to treat/manage diseases listed above * Work overnight shifts * Clinically diagnosed anxiety or depression * Pregnant or trying to become pregnant * Significant surgical history * Other significant medical conditions at investigator's discretion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood Pressure measured continuously over a period of 24 hour | Continuously over a 24-hour period | Utilize an ambulatory blood pressure monitor to measure blood pressure values continuously over a 24-hour period. |
| Neurovascular Control: Change in the brain blood flow | Baseline and 5 weeks | Change in brain blood flow will be measured using a transcranial Doppler ultrasound in response to a breathing test. |
| Neurovascular Control: Change in the blood pressure | Baseline and 5 weeks | Change in blood pressure in response to a breathing test. |
| Neurovascular Control: change in the sympathetic nerve activity | Baseline and 5 weeks | Change in sympathetic nerve activity will be measured using microneurography in response to a breathing test. |
Countries
United States
Outcome results
None listed