Obesity
Conditions
Brief summary
This study was aimed to investigate the associations between platelet number and 25(OH)D serum concentration in apparently healthy but overweight/obese subjects.
Detailed description
Subjects were enrolled at the first examination whether they were not taking any medication, including oral contraceptives or drugs for osteoporosis, and free of significant medical illnesses, except obesity. Exclusion criteria were history of endocrinological diseases (diabetes mellitus, hypo or hyperthyroidism, hypopituitarism, etc.), chronic inflammatory diseases, stable known hypertension, angina pectoris, stroke, transient ischemic attack, heart infarction, congenital heart disease, malignancies, chronic inflammatory diseases, renal and liver failure, angina pectoris, myocardial infarction, heart failure, congenital heart diseases, minor and major stroke, and inherited thrombocytopenias and other major malignancies. subjects were examined by means of the medical history, hormonal, metabolic and routine hematochemical parameters. We provided for a clinical baseline evaluation that included extemporaneous ambulatory blood pressure (BP) and a physical assessment of body weight, Body Mass Index (BMI) and Waist Circumference (WC) as anthropometric parameters. To lead the statistical analysis, all sample was clusterized into three different groups according to the diagnostic condition of deficiency (\<10 ng/mL), insufficiency (\<20 ng/mL) and sufficiency (≥20 ng/mL) of vitamin D. We labelled each cluster as group 1, group 2 and group 3.
Interventions
None listed
Sponsors
Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Overweight or obesity (BMI\> 25 Kg/m2)
Exclusion criteria
* Any kind of drug * Hypertension * Endocrine diseases (diabetes mellitus, hypo or hyperthyroidism, hypopituitarism, etc.), * Chronic inflammatory diseases * Renal failure * Liver failure * Angina pectoris * Myocardial infarction and heart failure * Genetic heart diseases * Thrombocytopenias
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vitamin D | At baseline | Vitamin D (ng/mL) concentration in serum |
| Platelets | At baseline | Platelets (cells/mm3) number in serum |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Creatinin | At baseline | Creatinin (mg/dl) concentration in serum |
| Total cholesterol | At baseline | Total cholesterol (mg/dL) concentrations in serum |
| Thyroid hormones (FT3, FT4) | At baseline | FT3 (pg/mL), FT4 (pg/mL) concentration in serum |
| HDL cholesterol | At baseline | HDL cholesterol (mg/dL) concentrations in serum |
| Insulin | At baseline | Insulin (mIU/L) concentration in serum |
| TSH | At baseline | TSH (mU/L) concentration in serum |
| BMI | At baseline | BMI (kg/m\^2) |
| Height | At baseline | Height in meters |
| Weight | At baseline | Weight in kilograms |
| LDL cholesterol | At baseline | LDL cholesterol (mg/dL) concentrations in serum |
| eGFR (estimated glomerular filtration rate) | At baseline | eGFR (ml/min/1.73 mq) |
Countries
Italy
Outcome results
None listed