Cerebral Oxygenation
Conditions
Brief summary
The brain is a very vulnerable organ, especially in premature babies, newborns and infants. However, during anesthesia, the oxygenation of the brain can only be monitored indirectly and insufficiently. Near-infrared spectroscopy (NIRS) is an established monitoring method in other areas (e.g., neonatology, cardiac anesthesia), which provides non-invasive information about the regional oxygen supply of the brain. The integration of this monitoring device into the anaesthesiological care for neonates and infants could reduce the risk of cerebral hypoxia. The planned study investigates whether the use of NIRS in anesthetized children up to 6 months can prevent or influence the occurrence of cerebral hypoxia.
Interventions
DIAGNOSTIC_TESTNIRS open
Treatment according to protocol in phases of cerebral hypoxia.
Sponsors
Medical University of Graz
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
No minimum to 6 Months
Healthy volunteers
No
Inclusion criteria
* Expected duration of Anesthesia \>45 minutes * Intervention/surgery in the operating room
Exclusion criteria
* Impossibility to place cerebral NIRS sensor * Known cerebral pathology * Missing parental consent * Congenial cardiac condition with right to left shunt * Cardiac surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cerebral hypoxic burden | 1 day | Time under 65% cerebral oxygen saturation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Fluid administration | 1 day | ml/kg |
| Number of participants with Vasopressor or Inotrope administered | 1 day | Proportion |
| Number of participants with erythrocyte administration | 1 day | Proportion |
| Fraction of inspired oxygen | 1 day | % |
Outcome results
None listed