Depression
Conditions
Brief summary
This study evaluates whether increasing sleep duration can increase neural and behavioral response to rewards and decrease depressive symptoms in 18- to 22-year-old women with insufficient sleep and depressive symptoms.
Interventions
BEHAVIORALTypical sleep opportunity
Typical sleep opportunity with consistent sleep timing for 1 week
BEHAVIORALExtended sleep opportunity
Extended sleep opportunity by 90 min per night with consistent sleep timing for 1 week
Sponsors
University of Oregon
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 22 Years
Healthy volunteers
No
Inclusion criteria
* Insufficient sleep (total sleep time \< 8 hours per night, with sleepiness scores ≥ 6 on the Epworth Sleepiness Scale OR ≥ 16 on the PROMIS Sleep Related Impairment Scale) * Symptoms of depression (≥ 15 on the Center for Epidemiological Studies for Depression Scale)
Exclusion criteria
* Current insomnia, hypersomnia, sleep disordered breathing, sleep movement disorder, or circadian rhythm disorder * History of head injury with loss of consciousness within the past two years * History of head injury with loss of consciousness two or more years ago and meet criteria for post concussion syndrome * Neurological disorder * Use of psychiatric medications * Current psychotic symptoms * Active suicidal ideation * Conditions that are contraindicated for MRI (e.g., ferromagnetic material in the body) * Meet criteria for current substance use disorder with greater than mild severity
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sleep duration | 1 week | Mean actigraphy-measured sleep duration |
| Depressive symptoms | 1 week | Center for Epidemiological Studies Depression Scale score. The CESD-R is a 20-item measure of the frequency of depressive symptoms, with each item rated on a scale from 0 (not at all or less than one day) to 5 (nearly every day). Total scores range from 0 to 100, with higher scores indicating greater number and frequency of depressive symptoms. |
| Reward-related brain function | 1 week | BOLD fMRI response during Reward Guessing Task |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Positive affect | 1 week | International Positive and Negative Affect Scale Short Form - Positive Affect score. The I-PANAS-SF is a 10-item scale that asks participants to rate the extent to which 5 positive and 5 negative adjectives describe them on a scale of 1 (never) to 5 (always). Scores for each positive adjective are summed to produce a Positive Affect (PA) score ranging from 5 to 25, with higher scores indicating more positive affect. |
| Reward-related functional connectivity | 1 week | BOLD fMRI psychophysiological striatal-medial prefrontal cortex interaction |
| Negative affect | 1 week | International Positive and Negative Affect Scale Short Form - Negative Affect score. The I-PANAS-SF is a 10-item scale that asks participants to rate the extent to which 5 positive and 5 negative adjectives describe them on a scale of 1 (never) to 5 (always). Scores for each negative adjective are summed to produce a Negative Affect (PA) score ranging from 5 to 25, with higher scores indicating more negative affect. |
| Reward effort | 1 week | Effort Expenditure for Rewards Task score |
Countries
United States
Outcome results
None listed