Critical Illness, Influenza
Conditions
Keywords
influenza, microbiota, intensive care unit
Brief summary
Influenza is a potentially lethal disease still responsible for thousands excess deaths both in Europe and the United States. Despite the use of neuraminidase inhibitors, its treatment is mostly based on symptomatic care. Lung microbiota has been shown to be involved in the immunity against influenza and is correlated with lung inflammation in numerous chronic respiratory diseases. We therefore aim to analyse the correlation between lung bacteriobiota and influenza ICU mortality
Detailed description
Influenza is a viral disease which is still responsible for thousands of excess deaths par year both in Europe and in the US. Despite the use of neuraminidase inhibitors, its treatment is mostly based on symptomatic care. As lung microbiota is correlated with lung inflammation in numerous chronic respiratory diseases, we hypothesize that lung microbiota would be correlated with influenza outcomes. In a pilot study, we found that lung bacteriobiota but not mycobiota is associated with influenza ICU mortality. We therefore aim to confirm this correlation between lung bacteriobiota and influenza mortality.
Interventions
DIAGNOSTIC_TESTinfluenza screening
positive influenza screening
Sponsors
University of Bordeaux
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient above 18 year-old admitted to intensive care unit * Influenza diagnosis by PCR or rapid diagnostic test
Exclusion criteria
* Guardianship or curatorship * Prisoners * No health insurance * No legal representative
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lung bacteriobiota and ICU mortality | at admission | Comparison of lung bacteriobiota alpha diversity between influenza ICU survivors and non-survivors |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Lung bacteriobiota and ICU mortality | at admission | Analysis of lung bacteriobiota beta diversity between influenza ICU survivors and non-survivors |
| Lung bacteriobiota and 7-day mortality | at admission | Analysis of lung bacteriobiota beta diversity between influenza 7-day survivors and non-survivors |
| Bacteria and ICU mortality | at admission | Association of bacteria with influenza ICU mortality by LefSe method |
| Bacteria and 7-day mortality | at admission | Association of bacteria with influenza 7-day mortality by LefSe method |
| ICU mortality based on Shannon index | at admission | Comparison of ICU mortality based on a threshold of 1.79 for Shannon Index |
Countries
France
Outcome results
None listed