Pain, Postoperative
Conditions
Keywords
Autologous fat grafting, Lipofilling, Breast cancer, Breast reconstruction
Brief summary
Autologous fat grafting, also known as lipofilling, is a surgical technique consisting in the processing and transfer of adipose tissue from one area in our organism (hips, thighs) to region which in need of reconstructive and aesthetic correction. The technique is frequently used after radical or conservative mammary surgery, aiming to achieve better aesthetic results, reduce pain induced by both surgery and radiotherapy. The scientific community was widely involved in the debate regarding the use of mesenchymal/stem cells in a patient with high risk of tumor progression due to their elevated proliferative profile. This study aims to retrospectively evaluate the oncological safety in the use of lipofilling in patients who underwent oncological and reconstructive treatment in our Institute.
Interventions
PROCEDUREAutologous fat grafting procedure
Surgical intervention based on the injection of autologous fat grafting after radical or conservative breast surgery and breast reconstruction.
PROCEDUREBreast reconstruction
Breast reconstructive procedures after oncological radical or conservative breast surgery
Sponsors
Humanitas Clinical and Research Center
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* female * breast carcinoma (any histological type, carcinoma in situ included) treated with radical or conservative surgery * group treated with lipofilling and group which didnt receive lipofilling * timing: retrospective evaluation of cases form 2006 to 2016, with a minimum of two year follow up
Exclusion criteria
* neoplasie different from infiltrating and in sutu breast carcinoma * in situ lobular carcinoma * patients with breast carcinoma and metastasis * lipofilling procedure used before the oncological treatment for breast carcinoma
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oncological safety of autologous fat grafting | Two years | Percentage of disease relapse in loco |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Establishment of timing in disease relapse | Two years | — |
| Establish the distribution in disease relapses | Two years | Establish the distribution in disease relapse in thre different histological subtypes of breast carcinoma |
| Establish overall survival rate in experimental and control groups | Two years | — |
Countries
Italy
Outcome results
None listed