Acute Kidney Injury
Conditions
Brief summary
Retrospective study that aims to examine the presence of acute kidney injury (AKI) during major abdominal surgery, non- cardiac surgery. Using clinical and biochemical data in order to establish AKI frequency and risk factors.
Detailed description
Ethical approval was submitted and approved by the regional ethical committee, Etisk prövningsnämnd Uppsala, # 2017/418. Patients were selected from the time span of april 2016 to september 2017. The investigators identified 499 patients that had undergone any of the selected procedures. The procedures were, pancreatic resection, HIPEC surgery in colorectal setting, gynecological debulking in metastasized ovarian cancer, and liver resection. The risk of acute kidney injury (AKI) by the KDIGO definition during the postoperative period will be estimated in the group as a whole, and for each type of surgery separately. In addition the data will be stratified by sex to investigate systematic gender disparities or physiological differences. Length of stay, thirty day and sixty day mortality will secondary endpoints.
Interventions
None listed
Sponsors
Uppsala University
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Inclusion criteria
Any of the selected procedures.
Exclusion criteria
Patient has expressed his or her will to nor participate in any study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of AKI | the first 24- 72 hours postop | Frequency of AKI as defined by KDIGO |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mortality | 30, 60 and 360 days postoperatively | 30, 60, and 360 day mortality rate |
| Major Adverse Kidney Events | 30, 60 and 360 days postoperatively | Renal composite outcome according to Major Adverse Kidney Events (MAKE) |
| Fluid balance | 24-72h | Fluid balance during surgery, and the first postoperative days. |
| Electrolyte disturbances | 24-72h | Any electrolyte disturbance. |
Outcome results
None listed