Ketamine for Acute Pain Management After Trauma

Time frame: In-hospital days (up to 6 weeks post hospital admission)

Length of time Ketamine drip was infused

Time frame: Hospital discharge (up to 6 weeks post hospital admission)

For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked to indicate their level of anxiety/depression by choosing a predefined category, and the data for this outcome are reported categorically as the number of participants who chose each category.

Time frame: 6 months post admission

Population: These data were not collected from 54 participants in the Usual Care arm and 44 in the Ketamine plus Usual Care arm.~2 participants in the Usual Care arm did not complete the Anxiety and Depression section in the survey.

For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked to indicate their level of anxiety/depression by choosing a predefined category, and the data for this outcome are reported categorically as the number of participants who chose each category.

Time frame: Hospital discharge (about 1 to 6 weeks after admission)

Population: These data were not collected from 27 participants in the Usual Care arm and 20 in the Ketamine plus Usual Care arm

For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked the question How would you rate your health today?, and they respond with a score from 0 - 100, with a higher score indicating a better outcome.

Time frame: 6 months post admission

Population: These data were not collected from 54 participants in the Usual Care arm and 44 in the Ketamine plus Usual Care arm.

For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked the question How would you rate your health today?, and they respond with a score from 0 - 100, with a higher score indicating a better outcome.

Time frame: Hospital discharge (about 1 to 6 weeks after admission)

Population: These data were not collected from 27 participants in the Usual Care arm and 20 in the Ketamine plus Usual Care arm

For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked to indicate their level of mobility by choosing a predefined category, and the data for this outcome are reported categorically as the number of participants who chose each category.

Time frame: Hospital discharge (about 1 to 6 weeks after admission)

Population: These data were not collected from 27 participants in the Usual Care arm and 20 in the Ketamine plus Usual Care arm

For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked to indicate their level of mobility by choosing a predefined category, and the data for this outcome are reported categorically as the number of participants who chose each category.

Time frame: 6 months post admission

Population: These data were not collected from 54 participants in the Usual Care arm and 44 in the Ketamine plus Usual Care arm.

For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked to indicate their level of pain/discomfort by choosing a predefined category, and the data for this outcome are reported categorically as the number of participants who chose each category.

Time frame: 6 months post admission

Population: These data were not collected from 54 participants in the Usual Care arm and 44 in the Ketamine plus Usual Care arm.

For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked to indicate their level of pain/discomfort by choosing a predefined category, and the data for this outcome are reported categorically as the number of participants who chose each category.

Time frame: Hospital discharge (about 1 to 6 weeks after admission)

Population: These data were not collected from 27 participants in the Usual Care arm and 20 in the Ketamine plus Usual Care arm

For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked the question Have you ever experience this kind of event?, and data are reported as the number of participants who responded yes.

Time frame: 6 months post admission

Population: These data were not collected from 54 participants in the Usual Care arm and 44 in the Ketamine plus Usual Care arm.

For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked the question Have you ever experience this kind of event?, and data are reported as the number of participants who responded yes.

Time frame: Hospital discharge (about 1 to 6 weeks after admission)

Population: These data were not collected from 27 participants in the Usual Care arm and 20 in the Ketamine plus Usual Care arm.

For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked to indicate their level of mobility by choosing a predefined category, and the data for this outcome are reported categorically as the number of participants who chose each category.

Time frame: 6 months post admission

Population: These data were not collected from 54 participants in the Usual Care arm and 44 in the Ketamine plus Usual Care arm.~1 participant in the Ketamine plus Usual Care arm did not complete the Self-Care section of the survey.

For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked to indicate their level of self-care by choosing a predefined category, and the data for this outcome are reported categorically as the number of participants who chose each category.

Time frame: Hospital discharge (about 1 to 6 weeks after admission)

For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked to indicate their ability to carry out usual activities by choosing a predefined category, and the data for this outcome are reported categorically as the number of participants who chose each category.

Time frame: 6 months post admission

Population: These data were not collected from 54 participants in the Usual Care arm and 44 in the Ketamine plus Usual Care arm.~1 participant in the Usual Care arm did not complete the Usual Activities section of the Survey

For this item of the Euro-QOL EQ-5D-3L questionnaire, participants are asked to indicate their ability to carry out usual activities by choosing a predefined category, and the data for this outcome are reported categorically as the number of participants who chose each category.

Time frame: Hospital discharge (about 1 to 6 weeks after admission)

Population: These data were not collected from 27 participants in the Usual Care arm and 20 in the Ketamine plus Usual Care arm

Number of days patients were not in the hospital during the first 30 days after admission

Time frame: 30 days post admission

Number of inpatient hospital days patients did not require ICU level of care

Time frame: Hospital discharge (up to 6 weeks post hospital admission)

Time from admission to time Ketamine drip started

Time frame: Hospital discharge (up to 6 weeks post hospital admission)

Population: Data were not collected for this outcome measure

Number of patients discharged from the hospital with an opioid prescription

Time frame: Hospital discharge (up to 6 weeks post hospital admission)

Number of patients requesting to stop Ketamine for any complaint

Time frame: Hospital discharge (up to 6 weeks post hospital admission)

incidence of need for unplanned intubation during in-hospital stay

Time frame: Hospital discharge (up to 6 weeks post hospital admission)

Incidence of delirium during in-hospital stay

Time frame: Hospital discharge (up to 6 weeks post hospital admission)

Number of patients who continue to use opioids

Time frame: 6 months post admission

Population: Data were not collected from 54 participants in the Usual Care arm and 44 in the Ketamine plus Usual Care arm.

Number of patients who reported continued pain at 6 months following trauma injury

Time frame: 6 months post admission

Population: Data were not collected from 54 participants in the Usual Care arm and 44 in the Ketamine plus Usual Care arm.

Incidence of need for unplanned admission to an ICU

Time frame: Hospital discharge (up to 6 weeks post hospital admission)

DVPRS scores were collected daily. For each participant, an average of the daily scores on the Defense and Veterans Pain Rating Scale was calculated. DVPRS scores range from 0 (no pain) to 10 (as bad as it could be, nothing else matters), with a higher score indicating a worse outcome.

Time frame: From time of admission to time of discharge from hospital (about 1 to 6 weeks after admission)

BPS score ranges from 3-12, with higher scores indicating worse pain. This assessment is used in non-verbal participants.

Time frame: Hospital discharge (up to 6 weeks post hospital admission)

Population: Data were not collected for this outcome measure

The NRS ranges from 0 (no pain) to 10 (worst pain), with a higher score indicating a worse outcome. This scale is used in verbal participants.

Time frame: Hospital discharge (up to 6 weeks post hospital admission)

Population: Data were not collected for this outcome measure

The PC-PTSD-5 questionnaire asks the below 5 questions, and data are reported categorically as the number of participants who responded yes to each of the 5 questions. An answer of yes is indicative of a PTSD symptom, which is a worse outcome. 1. In the past month, have you had nightmares about the events or thought about the events when you did not want to? 2. In the past month, have you tried hard not to think about the events or went out of your way to avoid situations that reminded you of the events? 3. In the past month, have you been constantly on guard, watchful, or easily startled? 4. In the past month, have you felt numb or detached from people, activities, or your surroundings? 5. In the past month, have you felt guilty or unable to stop blaming yourself or others for the events or any problems the events may have caused?

Time frame: 6 months post admission

Population: These data were not collected from 78 participants in the Usual Care arm and 75 in the Ketamine plus Usual Care arm

The PC-PTSD-5 questionnaire asks the below 5 questions, and data are reported categorically as the number of participants who responded yes to each of the 5 questions. An answer of yes is indicative of a PTSD symptom, which is a worse outcome. 1. In the past month, have you had nightmares about the events or thought about the events when you did not want to? 2. In the past month, have you tried hard not to think about the events or went out of your way to avoid situations that reminded you of the events? 3. In the past month, have you been constantly on guard, watchful, or easily startled? 4. In the past month, have you felt numb or detached from people, activities, or your surroundings? 5. In the past month, have you felt guilty or unable to stop blaming yourself or others for the events or any problems the events may have caused?

Time frame: Hospital discharge (about 1 to 6 weeks after admission)

Population: These data were not collected from 74 participants in the Usual Care arm and 67 in the Ketamine plus Usual Care arm.

Total ORT score ranges from 0 to 26. A score of 3 or lower indicates low risk for future opioid abuse, a score of 4 to 7 indicates moderate risk for opioid abuse, and a score of 8 or higher indicates a high risk for opioid abuse.

Time frame: Hospital discharge (about 1 to 6 weeks after admission)

Incidence of use of additional pain control adjuncts such as regional anesthesia and lidocaine patch during hospitalization

Time frame: Hospital discharge (up to 6 weeks post hospital admission)

Population: Lidocaine drip was not used in clinic.

Number of inpatient hospital days patients did not require mechanical ventilation

Time frame: Hospital discharge (up to 6 weeks post hospital admission)