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QUality Of Life and surviVAl in carDIac arreSt Patients

QUO VADIS - QUality Of Life and surviVAl in carDIac arreSt Patients

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04129073
Acronym
QUOVADIS
Enrollment
1600
Registered
2019-10-16
Start date
2022-12-01
Completion date
2026-11-30
Last updated
2022-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Arrest, Central Nervous System Diseases, Post-Anoxic Coma

Keywords

Comparative Effectiveness Research

Brief summary

QUO VADIS is a national observational study with the aim to describe clinical intervention and utilization of neuroprognostication tools in the management of patients admitted to ICU following cardiac arrest

Detailed description

Despite recent improvements in post-resuscitation care, about 50% of patients resuscitated from cardiac arrest die or have poor neurological prognosis. Post-anoxic brain injury is common after cardiac arrest and is a major cause of post-resuscitation mortality. Since there has been a significant investment in improving the emergency response to both in-hospital ad out-of-hospital cardiac arrest (IHCA and OHCA, respectevly) patients and reported improvements in short-term survival outcomes, the long-term neurological state and quality of life of survivors and their caregiver is of growing significance. QUO VADIS is a national observational study created to describe clinical interventions and utilization of neuroprognostication tools in the management of patients admitted to ICU following cardiac arrest. The aims of the study are: * To create an Italian Registry that describes clinical interventions and neuroprognostication tools used in the management of patients admitted to ICU following cardiac arrest * To evaluate, after one year from the cardiac arrest, the neurological outcome and the quality of life of the patients; * To evaluate, after one year from the cardiac arrest, the quality of life of caregivers; * To identify the most effective clinical intervention in the management of post-cardiac arrest patients admitted to ICU; * To create a prognostic model for patients admitted to ICU after cardiac arrest.

Interventions

Intensive care treatment; Utilization of neuroprognostication tools

Sponsors

Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
14 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Age ≥ 14 years; * Cardiac Arrest within 24 hours ICU admission

Exclusion criteria

* Absence of Informed consent; * Age \< 14 years

Design outcomes

Primary

MeasureTime frameDescription
Disability6 monthsGOSe (Glascow Outcome Scale extended). Minimum value: 1 = Dead; Maximum value: 8= Upper Good Recovery
Neurological Outcome6 monthsmRS (modified Ranking Scale) Minimum value: 0 = Complete recovery; Maximum value: 6 = Death
Patients quality of life12 monthsEuroQoL-5D (european quality of life 5 dimensions). 0 = Worst imaginable health state; 100 = best imaginable health state

Secondary

MeasureTime frameDescription
Caregiver quality of life12 monthsCaregiver Burden Inventory. 0 to 20 = little or no burden; 61 to 88 = severe burden

Contacts

Primary ContactElena Garbero, MSc
giviti@marionegri.it+390354535388
Backup ContactAlice Lavetti
giviti@marionegri.it+390354535313

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026