Cardiac Arrest, Central Nervous System Diseases, Post-Anoxic Coma
Conditions
Keywords
Comparative Effectiveness Research
Brief summary
QUO VADIS is a national observational study with the aim to describe clinical intervention and utilization of neuroprognostication tools in the management of patients admitted to ICU following cardiac arrest
Detailed description
Despite recent improvements in post-resuscitation care, about 50% of patients resuscitated from cardiac arrest die or have poor neurological prognosis. Post-anoxic brain injury is common after cardiac arrest and is a major cause of post-resuscitation mortality. Since there has been a significant investment in improving the emergency response to both in-hospital ad out-of-hospital cardiac arrest (IHCA and OHCA, respectevly) patients and reported improvements in short-term survival outcomes, the long-term neurological state and quality of life of survivors and their caregiver is of growing significance. QUO VADIS is a national observational study created to describe clinical interventions and utilization of neuroprognostication tools in the management of patients admitted to ICU following cardiac arrest. The aims of the study are: * To create an Italian Registry that describes clinical interventions and neuroprognostication tools used in the management of patients admitted to ICU following cardiac arrest * To evaluate, after one year from the cardiac arrest, the neurological outcome and the quality of life of the patients; * To evaluate, after one year from the cardiac arrest, the quality of life of caregivers; * To identify the most effective clinical intervention in the management of post-cardiac arrest patients admitted to ICU; * To create a prognostic model for patients admitted to ICU after cardiac arrest.
Interventions
Intensive care treatment; Utilization of neuroprognostication tools
Sponsors
Study design
Eligibility
Inclusion criteria
* Age ≥ 14 years; * Cardiac Arrest within 24 hours ICU admission
Exclusion criteria
* Absence of Informed consent; * Age \< 14 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Disability | 6 months | GOSe (Glascow Outcome Scale extended). Minimum value: 1 = Dead; Maximum value: 8= Upper Good Recovery |
| Neurological Outcome | 6 months | mRS (modified Ranking Scale) Minimum value: 0 = Complete recovery; Maximum value: 6 = Death |
| Patients quality of life | 12 months | EuroQoL-5D (european quality of life 5 dimensions). 0 = Worst imaginable health state; 100 = best imaginable health state |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Caregiver quality of life | 12 months | Caregiver Burden Inventory. 0 to 20 = little or no burden; 61 to 88 = severe burden |