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Decreasing the Temporal Window in Individuals With Alcohol Use Disorder

Reinforcer Pathology 1B: Decreasing the Temporal Window

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04128761
Acronym
RP1B
Enrollment
124
Registered
2019-10-16
Start date
2023-09-21
Completion date
2024-05-28
Last updated
2025-12-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alcohol Use Disorder

Keywords

Delay Discounting, Behavioral Economic Demand, Scarcity Narrative, Alcohol Craving

Brief summary

In the absence of sufficient monetary resources, individuals must attend to immediate, minimum needs (e.g., food, shelter). This constricts one's temporal window and engenders neglect of the future. In observational studies, scarcity is associated with higher rates of delay discounting. Additionally, socioeconomic status is inversely associated with alcohol use disorder and related problems. Experimentally, scarcity shortens attention, impedes cognitive function, and increases delay discounting in multiple populations. Moreover, scarcity increases demand for fast foods in the obese and increases craving for alcohol in problem drinkers. These data suggest that economic scarcity worsens both components of reinforcer pathology (delay discounting and alcohol overvaluation), thus increasing vulnerability to alcohol use disorder. However, studies investigating the effects of scarcity on alcohol demand discounting rate have been limited. The purpose of Aim 1b is to examine effects of decreasing the temporal window and its concomitant effects on alcohol valuation (demand, and craving) and delay discounting.

Detailed description

Participants will be randomly assigned to experimental or control groups, balanced by discounting rates and sex. We plan to have 112 participants complete the study, based on our power analysis. Participants will complete two online sessions. During the first session, they will complete the baseline assessments. During the second session, they will complete the same assessments after being exposed to the scarcity or control narratives (both in audio format). The assessment will include delay discounting and demand tasks, and measures of alcohol craving. Participants will also complete assessments of their stress and mood response to the narrative intervention, using the Stress Appraisal Measure (SAM) for two purposes. That is, 1) to monitor participant safety, 2) to measure the mediating ability of affect on changes in the temporal window.

Interventions

Participants are presented with a hypothetical scarcity narrative and asked to listen and consider the scenario.

Participants are presented with a hypothetical neutral narrative and asked to listen and consider the scenario.

Sponsors

National Institute on Alcohol Abuse and Alcoholism (NIAAA)
CollaboratorNIH
McMaster University
CollaboratorOTHER
Arizona State University
CollaboratorOTHER
Carilion Clinic
CollaboratorOTHER
University of Kentucky
CollaboratorOTHER
Virginia Polytechnic Institute and State University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* High-risk or harmful drinking (AUDIT\>15) * 21 years of age or older * Desire to quit or cut down on their drinking, but do not have proximate plans to enroll in treatment for AUD during the study period

Exclusion criteria

* having a current unmanaged psychotic disorder * reporting current pregnancy or lactation * having dementia

Design outcomes

Primary

MeasureTime frameDescription
Change in Alcohol CravingAt the first session (S1; baseline measures) and Session 2 (S2; occurs approximately 2-3 days after S1)A brief questionnaire (the Alcohol Urges Questionnaire) will be used to assess alcohol craving. The Alcohol Urges Questionnaire is an 8-item survey that produces scores between 8-56, where higher scores indicate greater craving. Change in alcohol craving will be compared within-subjects between Session 1 and Session 2. The scores will be compared between groups (arms) across sessions.
Delay Discounting (DD) RatesAt the first session (S1; baseline measures) and Session 2 (S2; occurs approximately 2-3 days after S1)DD rates were measured using an adjusting amount task where participants were presented with hypothetical choices between smaller immediate or larger later amounts of money after a range of delays (1 day-25 years). Individual indifference points were calculated for each delay and then used to estimate DD rates for each participant using Mazur's (1987) equation: V = A/(1+kD), where V is the value of the indifference point, A is the amount of the larger delayed reward, k is the discounting rate, and D is the delay. Discounting rates (k) were then natural-logarithmically transformed (ln(k)). Higher ln(k) indicates steeper discounting and greater reward devaluation with increases in delay, while a lower ln(k) reflects shallower discounting and less reward devaluation with increases in delay. Changes in ln(k) were compared within-subjects between S1 and S2. Average ln(k) was calculated for each session (S1 and S2) in each condition (scarcity or neutral).
Intensity of Alcohol DemandAt the first session (S1; baseline measures) and Session 2 (S2; occurs approximately 2-3 days after S1)Participants completed a hypothetical Alcohol Purchase Task where they had to indicate how many drinks they would purchase at different prices ($0 to $80 per drink). The number of drinks purchased at $0 was used to calculate the intensity of demand. Changes in intensity of alcohol demand were compared within-subjects between Session 1 and Session 2, and between narrative type (scarcity or neutral).

Secondary

MeasureTime frameDescription
Change in Stress Appraisal MeasureSession 2 (occurs approximately 2-3 days after baseline [S1])The Stress Appraisal Measure will be used to measure acute stress induced by the intervention. This measure is a 28-item survey that produces scores between 28-140, where higher scores indicate greater stress. Change scores were compared between groups during Session 2, to assess differences in stress level as a function of the narrative presented.

Countries

United States

Participant flow

Participants by arm

ArmCount
Scarcity Narrative
Participants assigned to the scarcity group will be asked to listen and consider a hypothetical narrative about a sudden loss of resources. Scarcity Narrative: Participants are presented with a hypothetical scarcity narrative and asked to listen and consider the scenario.
40
Neutral Narrative
Participants assigned to the neutral group will be asked to listen and consider a hypothetical narrative about a neutral change in resources. Neutral Narrative: Participants are presented with a hypothetical neutral narrative and asked to listen and consider the scenario.
45
Total85

Withdrawals & dropouts

PeriodReasonFG000FG001
Overall StudyLost to Follow-up56

Baseline characteristics

CharacteristicScarcity NarrativeNeutral NarrativeTotal
Age, Categorical
<=18 years
0 Participants0 Participants0 Participants
Age, Categorical
>=65 years
1 Participants1 Participants2 Participants
Age, Categorical
Between 18 and 65 years
39 Participants44 Participants83 Participants
Age, Continuous42.27 years
STANDARD_DEVIATION 11.22
42.84 years
STANDARD_DEVIATION 10.54
42.58 years
STANDARD_DEVIATION 10.8
Ethnicity (NIH/OMB)
Hispanic or Latino
1 Participants3 Participants4 Participants
Ethnicity (NIH/OMB)
Not Hispanic or Latino
39 Participants42 Participants81 Participants
Ethnicity (NIH/OMB)
Unknown or Not Reported
0 Participants0 Participants0 Participants
Region of Enrollment
United States
40 Participants45 Participants85 Participants
Sex: Female, Male
Female
23 Participants27 Participants50 Participants
Sex: Female, Male
Male
17 Participants18 Participants35 Participants

Adverse events

Event typeEG000
affected / at risk
EG001
affected / at risk
deaths
Total, all-cause mortality
0 / 620 / 62
other
Total, other adverse events
0 / 620 / 62
serious
Total, serious adverse events
0 / 620 / 62

Outcome results

Primary

Change in Alcohol Craving

A brief questionnaire (the Alcohol Urges Questionnaire) will be used to assess alcohol craving. The Alcohol Urges Questionnaire is an 8-item survey that produces scores between 8-56, where higher scores indicate greater craving. Change in alcohol craving will be compared within-subjects between Session 1 and Session 2. The scores will be compared between groups (arms) across sessions.

Time frame: At the first session (S1; baseline measures) and Session 2 (S2; occurs approximately 2-3 days after S1)

Population: A total of 124 participants enrolled in the study, with 112 participants (the proposed sample size) completing both sessions. We had additional attrition in the data inspection stage. Participants were included in the analyses if they: 1) completed both sessions, and 2) passed all attention checks programmed in the surveys for both sessions.

ArmMeasureGroupValue (MEAN)Dispersion
Scarcity NarrativeChange in Alcohol CravingSession 134.4 score on a scaleStandard Error 1.98
Scarcity NarrativeChange in Alcohol CravingSession 232.17 score on a scaleStandard Error 2.23
Neutral NarrativeChange in Alcohol CravingSession 133.11 score on a scaleStandard Error 1.87
Neutral NarrativeChange in Alcohol CravingSession 232.58 score on a scaleStandard Error 1.83
Comparison: The effects of narrative type alcohol craving were evaluated using a two-way (Scarcity vs. Session) repeated-measures ANOVA.p-value: 0.88ANOVA
Primary

Delay Discounting (DD) Rates

DD rates were measured using an adjusting amount task where participants were presented with hypothetical choices between smaller immediate or larger later amounts of money after a range of delays (1 day-25 years). Individual indifference points were calculated for each delay and then used to estimate DD rates for each participant using Mazur's (1987) equation: V = A/(1+kD), where V is the value of the indifference point, A is the amount of the larger delayed reward, k is the discounting rate, and D is the delay. Discounting rates (k) were then natural-logarithmically transformed (ln(k)). Higher ln(k) indicates steeper discounting and greater reward devaluation with increases in delay, while a lower ln(k) reflects shallower discounting and less reward devaluation with increases in delay. Changes in ln(k) were compared within-subjects between S1 and S2. Average ln(k) was calculated for each session (S1 and S2) in each condition (scarcity or neutral).

Time frame: At the first session (S1; baseline measures) and Session 2 (S2; occurs approximately 2-3 days after S1)

Population: A total of 124 participants enrolled in the study, with 112 participants (the proposed sample size) completing both sessions. We had additional attrition in the data inspection stage. Participants were included in the analyses if they: 1) completed both sessions, and 2) passed all attention checks programmed in the surveys for both sessions.

ArmMeasureGroupValue (MEAN)Dispersion
Scarcity NarrativeDelay Discounting (DD) RatesSession 2-4.92 ln(K-value)Standard Error 0.4
Scarcity NarrativeDelay Discounting (DD) RatesSession 1-4.69 ln(K-value)Standard Error 0.38
Neutral NarrativeDelay Discounting (DD) RatesSession 2-5.58 ln(K-value)Standard Error 0.37
Neutral NarrativeDelay Discounting (DD) RatesSession 1-5.15 ln(K-value)Standard Error 0.38
Comparison: The effects of narrative type on delay discounting rates were evaluated using a two-way (Scarcity vs. Session) repeated-measures ANOVA.p-value: 0.6ANOVA
Primary

Intensity of Alcohol Demand

Participants completed a hypothetical Alcohol Purchase Task where they had to indicate how many drinks they would purchase at different prices ($0 to $80 per drink). The number of drinks purchased at $0 was used to calculate the intensity of demand. Changes in intensity of alcohol demand were compared within-subjects between Session 1 and Session 2, and between narrative type (scarcity or neutral).

Time frame: At the first session (S1; baseline measures) and Session 2 (S2; occurs approximately 2-3 days after S1)

Population: A total of 124 participants enrolled in the study, with 112 participants (the proposed sample size) completing both sessions. We had additional attrition in the data inspection stage. Participants were included in the analyses if they: 1) completed both sessions, and 2) passed all attention checks programmed in the surveys for both sessions.

ArmMeasureGroupValue (MEAN)Dispersion
Scarcity NarrativeIntensity of Alcohol DemandSession 114.17 DrinksStandard Error 1.53
Scarcity NarrativeIntensity of Alcohol DemandSession 211.95 DrinksStandard Error 1.26
Neutral NarrativeIntensity of Alcohol DemandSession 116.22 DrinksStandard Error 2.55
Neutral NarrativeIntensity of Alcohol DemandSession 214.91 DrinksStandard Error 2.37
Comparison: The effects of narrative type on intensity of alcohol demand were evaluated using a two-way (Scarcity vs. Session) repeated-measures ANOVA.p-value: 0.54ANOVA
Secondary

Change in Stress Appraisal Measure

The Stress Appraisal Measure will be used to measure acute stress induced by the intervention. This measure is a 28-item survey that produces scores between 28-140, where higher scores indicate greater stress. Change scores were compared between groups during Session 2, to assess differences in stress level as a function of the narrative presented.

Time frame: Session 2 (occurs approximately 2-3 days after baseline [S1])

Population: A total of 124 participants enrolled in the study, with 112 participants (the proposed sample size) completing both sessions. We had additional attrition in the data inspection stage. Participants were included in the analyses if they: 1) completed both sessions, and 2) passed all attention checks programmed in the surveys for both sessions.

ArmMeasureValue (MEAN)Dispersion
Scarcity NarrativeChange in Stress Appraisal Measure88.52 score on a scaleStandard Error 2.14
Neutral NarrativeChange in Stress Appraisal Measure73.49 score on a scaleStandard Error 2.02
Comparison: The effects of narrative type on stress was evaluated using a one-way ANOVA.p-value: <0.001ANOVA

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026