Aged, Anesthesia, Spinal, Cerebrospinal Fluid, Flurbiprofen Axetil
Conditions
Keywords
S-flurbiprofen, R-flurbiprofen, cerebrospinal fluid, aged
Brief summary
The project will apply the methods of clinical observation experiment to study the central transport characteristics of flurbiprofen axetil by detecting S-flurbiprofen and R-flurbiprofen concentrations in cerebral-spinal fluid(CSF) after intravenous injection of flurbiprofen axetil in elderly patients.
Detailed description
The patients undergoing spinal anesthesia for lower extremity surgery will be studied. Flurbiprofen axetil 100mg will be injected intravenously. CSF 1ml and blood 2ml will be obtained simultaneously every 5 minutes after intravenous injection in 50 min( T1\ T10).CSF and blood samples will be used to detected S-flurbiprofen and R-flurbiprofen concentrations by using Liquid Chromatography-Mass Spectrometry. And the CSF/blood S-flurbiprofen and R-flurbiprofen concentrations ratio were calculated.
Interventions
None listed
Sponsors
Yi Feng, MD
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients undergoing lower extremity surgery under spinal or combined spinal-epidural anesthesia will be selected.
Exclusion criteria
* asthma, liver insufficiency, renal insufficiency, peptic ulcer, allergy to NSAIDs, and a history use of NSAIDs within two weeks before operation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The concentrations of S-flurbiprofen and R-flurbiprofen in plasma and CSF of all patients. | perioperation | The samples will be used to be determined plasma and CSF drug concentrations. |
Countries
China
Contacts
Primary ContactYi Feng, MD
Backup ContactHan Yao
Outcome results
None listed