Myocardial Infarction
Conditions
Brief summary
The aim of this study is to determine the miRNA expression profile in peripheral blood exosomes of patients with myocardial infarction and to investigate its relationship with myocardial infarction.
Detailed description
Collect exosomes in peripheral blood of patients with myocardial infarction, compare the expression of miRNA with healthy volunteers, find out the miRNAs with significant differences, and explore its relationship with the development of myocardial infarction.
Interventions
OTHERexosome
Collect exosomes in peripheral blood of patients and extract miRNAs from them.
Sponsors
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* Age \> 18 years ST elevation by ECG diagnostic of STEMI Evidency of coronary occlusion in coronariography Signed informed consent
Exclusion criteria
* Patients who will undergo immediate PCI Pregnant and lactating women Patients with mental disorders Patients are using other experimental drugs; Refusal to provide informed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determination of differential expression of miRNA by second-generation sequencing technology | Day 7 |
Secondary
| Measure | Time frame |
|---|---|
| Diagnostic value of the differential microRNAs evaluate by qPCR in patients of myocardial infarction | Day 7 |
Countries
China
Contacts
Primary ContactBin He
Outcome results
None listed