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The Mechanism of Dexmedetomidine in Improving Delirium After Cardiac Surgery

The Mechanism of Dexmedetomidine in Improving Delirium After Cardiac Surgery

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04127500
Enrollment
200
Registered
2019-10-15
Start date
2019-08-01
Completion date
2020-08-31
Last updated
2019-10-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Surgery, Delirium, Dexmedetomidine

Brief summary

The investigators aim to evaluate the roles of α7nAchR in the mechanisms of dexmedetomidine in improving delirium after cardiac surgery. The results of this study would lay the foundation for revealing the mechanisms of dexmedetomidine improving delirium after cardiac surgery and provide a new idea to the early treatment of delirium.

Interventions

DRUGdexmedetomidine

dexmedetomidine

Sponsors

Nanjing First Hospital, Nanjing Medical University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender
ALL
Age
60 Years to 100 Years
Healthy volunteers
No

Inclusion criteria

* ICU patients underwent cardiac surgery * age ≥ 60 years

Exclusion criteria

* Preoperative cognitive decline, mental illness, * preoperative long-term use of hormone patients, * preoperative alcohol dependence, * patients with alcohol withdrawal symptoms

Design outcomes

Primary

MeasureTime frame
delirium incidence1 month
α7nAChR level7 days

Secondary

MeasureTime frame
mechanical ventilation time7 days
ICU stay time1 month

Countries

China

Contacts

Primary ContactQiankun Shi, Doctor
hlblade@gmail.com+8613851420762

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026