Peritonitis
Conditions
Brief summary
When there is infection in the intra-abdominal area, bacteria secrete toxins that are absorbed by the peritoneum. These toxins then bind to lipoproteins (which carry cholesterol in the blood) and are eliminated by the liver. Phospholipid transfer protein (PLTP) is a protein that facilitates the binding of bacterial toxins to lipoproteins and thus their elimination. The objective of this study is to study the relationship between PLTP and the elimination of bacterial toxins in humans. A better understanding of the elimination of these toxins will lead to a better understanding of the disease. The ultimate objective is to improve the management of intra-abdominal infections.
Interventions
BIOLOGICALblood samples
4 blood samples of 6 ml each: one before the surgical incision, one after the operation, one 4h after the operation and the last 24h after the operation.
Sponsors
Centre Hospitalier Universitaire Dijon
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* person who has given oral consent (patient or family member) * pre-operative SEPSIS criteria (qSOFA \>=2) or vasopressor or mechanical ventilation treatment * admitted to the operating room for suspected generalized secondary peritonitis
Exclusion criteria
* person not affiliated to national health insurance * person under legal protection (curatorship, guardianship) * person under court order * pregnant, parturient or breastfeeding woman * minor * immunosuppression (HIV infection, corticosteroid treatment \> 0.15 mg/kg/day prednisolone equivalent \> 2 weeks, immunosuppressive treatment, primary cellular immune deficiency) * decision to limit or stop therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perioperative plasma concentration in 3HM | 24 hours postoperatively |
Countries
France
Outcome results
None listed