Healthy
Conditions
Keywords
Resync, Nitrate, Nitrite, Healthy
Brief summary
This study evaluates acute ingestion of the dietary supplement Resync on blood nitrate/nitrite concentrations in a sample of men and women. This will be a crossover trial in which participants take all 4 conditions: 1) 7.5g Resync, 2) 15g Resync, 3) 20g Resync+collagen, 4) placebo.
Detailed description
The product known as Resync contains a blend of nitrate-rich foods including beetroot, red spinach, turmeric, ginger root, and aronia berry extracts. Resync is sold commercially and marketed as an ergogenic aid and/or exercise recovery aid. Manufacturers of Resync recommend users take this product 60-90 minutes before an athletic event or 30-90 minutes after exercise. Resync bases these claims on prior studies investigating the individual ingredients' abilities to increase blood nitrate/nitrite levels; however, there are no clinical trials on the finished product itself. The purpose of this pilot study is to determine the impact of acute, single ingestion of Resync products on blood nitrate/nitrite concentration in a sample of men and women. This will be a crossover trial in which participants take all 4 conditions: 1) 7.5g Resync, 2) 15g Resync, 3) 20g Resync+collagen, 4) placebo.
Interventions
DIETARY_SUPPLEMENTResync
The product known as Resync contains a blend of nitrate-rich foods including beetroot, red spinach, turmeric, ginger root, and aronia berry extracts. Resync is sold commercially and marketed as an ergogenic aid and/or exercise recovery aid.
DIETARY_SUPPLEMENTResync + Collagen
17g Collagen + 2g Resync + 1g Carbohydrate
OTHERPlacebo
12oz water + food coloring
Sponsors
Resync, LLC
University of Memphis
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Masking description
Single-Blind
Intervention model description
Single-blind, pre-post ingestion, control
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI 18 - 29.9 kg/m2 * Non-smoker * Non-vegan * Not using nitrate-based dietary supplements
Exclusion criteria
* Diagnosed history of diabetes * Diagnosed history of cardiovascular disease * Diagnosed history of neurological disease * Pregnant females
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in diastolic blood pressure from daily baseline with placebo | 75-minutes post supplement ingestion | We will determine the change in daily diastolic blood pressure with supplementation from the daily baseline diastolic blood pressure with 12oz of food colored water. A red food dye will be used to match coloring of supplements. |
| Change in systolic blood pressure from daily baseline with placebo | 75-minutes post supplement ingestion | We will determine the change in daily systolic blood pressure with supplementation from the daily baseline systolic blood pressure with 12oz of food colored water. A red food dye will be used to match coloring of supplements. |
| Change in diastolic blood pressure from daily baseline with 7.5g Resync | 75-minutes post supplement ingestion | We will determine the change in daily diastolic blood pressure with supplementation from the daily baseline diastolic blood pressure with 1 serving (7.5g) of Resync. Resync powder will be mixed with 12oz of water. |
| Change in diastolic blood pressure from daily baseline with 15g Resync | 75-minutes post supplement ingestion | We will determine the change in daily diastolic blood pressure with supplementation from the daily baseline diastolic blood pressure with 2 servings (15g) of Resync. Resync powder will be mixed with 12oz of water. |
| Change in diastolic blood pressure from daily baseline with 20g Resync+Collagen | 75-minutes post supplement ingestion | We will determine the change in daily diastolic blood pressure with supplementation from the daily baseline diastolic blood pressure with 1 serving (20g) of Resync+Collagen. This blend contains approximately 17g of collagen, 2 g of Resync, and 1g carbohydrates. Resync+Collagen powder will be mixed with 12oz of water. |
| Change in blood nitrate+nitrite levels from daily baseline with 7.5g Resync | 75-minutes post supplement ingestion | We will determine the change in daily blood nitrate+nitrite from the daily baseline blood nitrate+nitrite with 1 serving (7.5g) of Resync. Resync powder will be mixed with 12oz of water. |
| Change in blood nitrate+nitrite levels from daily baseline with 15g Resync | 75-minutes post supplement ingestion | We will determine the change in daily blood nitrate+nitrite from the daily baseline blood nitrate+nitrite with 2 servings (15g) of Resync. Resync powder will be mixed with 12oz of water. |
| Change in blood nitrate+nitrite levels from daily baseline with 20g Resync+Collagen | 75-minutes post supplement ingestion | We will determine the change in daily blood nitrate+nitrite from the daily baseline blood nitrate+nitrite with 1 serving (20g) of Resync+Collagen. This blend contains approximately 17g of collagen, 2 g of Resync, and 1g carbohydrates. Resync+Collagen powder will be mixed with 12oz of water. |
| Change in blood nitrate+nitrite levels from daily baseline with placebo. | 75-minutes post supplement ingestion | We will determine the change in daily blood nitrate+nitrite from the daily baseline blood nitrate+nitrite with 12oz of food colored water. A red food dye will be used to match coloring of supplements. |
| Change in systolic blood pressure from daily baseline with 7.5g Resync | 75-minutes post supplement ingestion | We will determine the change in daily systolic blood pressure with supplementation from the daily baseline systolic blood pressure with 1 serving (7.5g) of Resync. Resync powder will be mixed with 12oz of water. |
| Change in systolic blood pressure from daily baseline with 15g Resync | 75-minutes post supplement ingestion | We will determine the change in daily systolic blood pressure with supplementation from the daily baseline systolic blood pressure with 2 servings (15g) of Resync. Resync powder will be mixed with 12oz of water. |
| Change in systolic blood pressure from daily baseline with 20g Resync+Collagen | 75-minutes post supplement ingestion | We will determine the change in daily systolic blood pressure with supplementation from the daily baseline systolic blood pressure with 1 serving (20g) of Resync+Collagen. This blend contains approximately 17g of collagen, 2 g of Resync, and 1g carbohydrates. Resync+Collagen powder will be mixed with 12oz of water. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in heart rate from daily baseline with 15g Resync | 75-minutes post supplement ingestion | We will determine the change in daily heart rate with supplementation from the daily baseline heart rate with 2 servings (15g) of Resync. Resync powder will be mixed with 12oz of water. |
| Change in heart rate from daily baseline with placebo | 75-minutes post supplement ingestion | We will determine the change in daily heart rate with supplementation from the daily baseline heart rate with 12oz of food colored water. A red food dye will be used to match coloring of supplements. |
| Change in heart rate from daily baseline with 20g Resync+Collagen | 75-minutes post supplement ingestion | We will determine the change in daily heart rate with supplementation from the daily baseline heart rate with 1 serving (20g) of Resync+Collagen. This blend contains approximately 17g of collagen, 2 g of Resync, and 1g carbohydrates. Resync+Collagen powder will be mixed with 12oz of water. |
| Change in heart rate from daily baseline with 7.5g Resync | 75-minutes post supplement ingestion | We will determine the change in daily heart rate with supplementation from the daily baseline heart rate with 1 serving (7.5g) of Resync. Resync powder will be mixed with 12oz of water. |
Countries
United States
Outcome results
None listed